U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hba-a2 hemoglobin alpha, adult chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 110257, updated on 8-Feb-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hba-a2provided by MGI
    Official Full Name
    hemoglobin alpha, adult chain 2provided by MGI
    Primary source
    MGI:MGI:96016
    See related
    Ensembl:ENSMUSG00000069917 AllianceGenome:MGI:96016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within erythrocyte development; in utero embryonic development; and response to bacterium. Is expressed in visceral pericardium and yolk sac. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 52386.2), heart adult (RPKM 17186.2) and 4 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 A4; 11 18.87 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32246492..32247310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32296492..32297310)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hemoglobin alpha, adult chain 1 Neighboring gene hemoglobin, theta 1B Neighboring gene hemoglobin, theta 1A Neighboring gene predicted gene, 46275

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Polymorphism and gene conversion in mouse alpha-globin haplotypes. Erhart MA, et al. Genetics, 1987 Mar. PMID 3032738, Free PMC Article
    2. Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia. Chang JC, et al. Proc Natl Acad Sci U S A, 1998 Dec 8. PMID 9843985, Free PMC Article
    3. Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease. Chang J, et al. Blood, 1996 Sep 1. PMID 8781443
    4. Characterization and kinetics of synthesis of 15S beta-globin RNA, a putative precursor of beta-globin mRNA. Curtis PJ, et al. Cold Spring Harb Symp Quant Biol, 1978. PMID 277329
    5. A conserved, extended chromatin opening within alpha-globin locus during development. Fu XH, et al. Exp Cell Res, 2005 Sep 10. PMID 16002065

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Radiation induced (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to haptoglobin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of haptoglobin-hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    hemoglobin alpha, adult chain 2
    Names
    alpha 2 globin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083955.1 → NP_001077424.1  hemoglobin alpha, adult chain 2

      See identical proteins and their annotated locations for NP_001077424.1

      Status: VALIDATED

      Source sequence(s)
      AK005434, CF740193
      Consensus CDS
      CCDS48766.1
      UniProtKB/Swiss-Prot
      P01942
      UniProtKB/TrEMBL
      A8DUV3, Q8BPF4, Q91VB8, Q9CWS5, Q9CY06
      Related
      ENSMUSP00000090895.4, ENSMUST00000093207.4
      Conserved Domains (1) summary
      cd08927
      Location:3 → 142
      Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      32246492..32247310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous