Socs4 suppressor of cytokine signaling 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Socs4provided by MGI
Official Full Name: suppressor of cytokine signaling 4provided by MGI
Primary source: MGI:MGI:1914546
See related: Ensembl:ENSMUSG00000048379 AllianceGenome:MGI:1914546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Socs7; 3110032M18Rik; A730004F22Rik
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within negative regulation of signal transduction and regulation of growth. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in ganglia; sensory organ; thymus primordium; and ventricular layer. Orthologous to human SOCS4 (suppressor of cytokine signaling 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 5.2), CNS E11.5 (RPKM 4.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 24.6 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (47514377..47533559)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (47276920..47296102)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance.
Title: In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance.
dispensable for immunological memory response to influenza virus infection
Title: SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.
SOCS4 is a critical regulator of anti-viral immunity.
Title: Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence.
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
Negative regulation of the JAK/STAT pathway is controlled by SOCS4, which target members of negative feedback loops, to suppress follicle growth and development.
Title: Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation.
Socs4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Title: ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237172

AI427843 (e-PCR)
- UniSTS:160381

AU015727 (e-PCR)
- UniSTS:180641

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: suppressor of cytokine signaling 4

Names: SOCS-4; SOCS-7; suppressor of cytokine signaling 7; suppressor of cytokine signalling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080843.3 → NP_543119.2 suppressor of cytokine signaling 4

See identical proteins and their annotated locations for NP_543119.2

Status: VALIDATED

Source sequence(s)

AC156016, AK014115, AW046781, BG083279, CJ121925

Consensus CDS

CCDS26985.1

UniProtKB/Swiss-Prot

Q149F7, Q149F8, Q91ZA6

Related

ENSMUSP00000066031.5, ENSMUST00000065562.6

Conserved Domains (3) summary

cd10385
Location:272 → 372

SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03738
Location:381 → 436

SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

pfam12610
Location:58 → 106

SOCS; Suppressor of cytokine signalling