Nrxn3 neurexin III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrxn3provided by MGI
Official Full Name: neurexin IIIprovided by MGI
Primary source: MGI:MGI:1096389
See related: Ensembl:ENSMUSG00000066392 AllianceGenome:MGI:1096389
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]
Expression: Biased expression in frontal lobe adult (RPKM 7.6), cerebellum adult (RPKM 6.7) and 6 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12 D3; 12 42.94 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (88689454..90301709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (88722701..90334935)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Title: Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
NRXN3 mutations cause developmental delay, movement disorder, and behavioral problems: CRISPR edited cells based WES results.
Title: NRXN3 mutations cause developmental delay, movement disorder, and behavioral problems: CRISPR edited cells based WES results.
A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop.
Title: A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop.
Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Title: Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum.
Title: Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum.
Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Title: Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Alternative splicing of neurexin-3 at SS4 suppressed AMPA-receptor-mediated, but not NMDA-receptor-mediated, synaptic responses.
Title: Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.
Mice of the 129 strain carry a unique missense variant in neurexin 3 and exhibit a profound and selective enhancement in observational fear.
Title: A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse.
In the present study, we report that Nrxn3beta is processed by the metalloproteases ADAM10, ADAM17, and by the intramembrane-cleaving protease gamma-secretase, producing secreted neurexin3beta (sNrxn3beta) and a single intracellular domain (Nrxn3beta-ICD). Thea authors show that sNrxn3beta produced by the cells of the dentate gyrus increases the spine density of newborn neurons.
Title: Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.
Nrxn3 is responsible for the neuroligins (NLs)-induced assembly of GABAergic synapses in co-culture. Importantly, lentivirus-based expression of Nrxn3 containing exon 20 restores the reduced NLs-induced GABAergic contacts in the SLM2 E/E co-culture.
Title: Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transposon induced (2) 1 citation
Targeted (6) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D12Bwg0831e (e-PCR), detects polymorphism
- UniSTS:141837

Serinc5 (e-PCR), detects polymorphism
- UniSTS:498446

D12Mit230 (e-PCR), detects polymorphism
- UniSTS:126785

R74682 (e-PCR)
- UniSTS:125508

D12Dcr9 (e-PCR), detects polymorphism
- UniSTS:507492

D12Mit276 (e-PCR), detects polymorphism
- UniSTS:126835

16.MHAa65T_M13Rev.seq (e-PCR)
- UniSTS:123287

BE115916 (e-PCR)
- UniSTS:248243

C86123 (e-PCR)
- UniSTS:165835

D12Mit117 (e-PCR), detects polymorphism
- UniSTS:126668

BB379399 (e-PCR)
- UniSTS:208846

R74682 (e-PCR)
- UniSTS:180435

MHAa85g8.seq (e-PCR)
- UniSTS:125404

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in trans-synaptic signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynaptic membrane	ISA Inferred from Sequence Alignment more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: neurexin 3

Names: neurexin-3-alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198587.4 → NP_001185516.2 neurexin 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_001185516.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This variant encodes an alpha isoform of neurexin 3.

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613

Consensus CDS

CCDS56856.1

UniProtKB/Swiss-Prot

E9PW93, E9Q466, Q6P9K9, Q8CCT8

UniProtKB/TrEMBL

E9Q2X2

Related

ENSMUSP00000129678.2, ENSMUST00000163134.8

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1497 → 1532

Syndecan; Syndecan domain

pfam02210
Location:899 → 1024

Laminin_G_2; Laminin G domain
NM_001252074.2 → NP_001239003.1 neurexin 3 isoform 3 precursor

See identical proteins and their annotated locations for NP_001239003.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform of neurexin 3.

Source sequence(s)

AK034555, AK042730, AK162558, BM942887, CR974428

Consensus CDS

CCDS79143.1

UniProtKB/Swiss-Prot

E9Q3Q9, Q8C985

Related

ENSMUSP00000105757.4, ENSMUST00000110130.4

Conserved Domains (2) summary

cd00110
Location:84 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:493 → 528

Syndecan; Syndecan domain
NM_001422338.1 → NP_001409267.1 neurexin 3 isoform 4

Status: REVIEWED

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613
NM_001422341.1 → NP_001409270.1 neurexin 3 isoform 6

Status: REVIEWED

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613
NM_001422342.1 → NP_001409271.1 neurexin 3 isoform 7

Status: REVIEWED

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613
NM_001422343.1 → NP_001409272.1 neurexin 3 isoform 8

Status: REVIEWED

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613
NM_001422344.1 → NP_001409273.1 neurexin 3 isoform 9

Status: REVIEWED

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613
NM_001422396.1 → NP_001409325.1 neurexin 3 isoform 10

Status: REVIEWED

Source sequence(s)

AC115744, AC120383, AC154495, AC155274, AC156637, AC161049, AC171335, CR974583, CT009613
NM_172544.3 → NP_766132.2 neurexin 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK032126, AK034555, AK162558, BM942887, CJ104960, CT009613

Consensus CDS

CCDS49134.1

UniProtKB/TrEMBL

Q6ZQ56

Related

ENSMUSP00000050075.8, ENSMUST00000057634.14

Conserved Domains (5) summary

smart00282
Location:97 → 246

LamG; Laminin G domain

cd00054
Location:274 → 307

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:727 → 906

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1026 → 1061

Syndecan; Syndecan domain

pfam02210
Location:526 → 654

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

88689454..90301709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157242.1 → XP_036013135.1 neurexin 3 isoform X17

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1399 → 1434

Syndecan; Syndecan domain

pfam02210
Location:899 → 1027

Laminin_G_2; Laminin G domain
XM_036157239.1 → XP_036013132.1 neurexin 3 isoform X14

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1467 → 1502

Syndecan; Syndecan domain

pfam02210
Location:890 → 1018

Laminin_G_2; Laminin G domain
XM_036157229.1 → XP_036013122.1 neurexin 3 isoform X1

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1510 → 1545

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_036157241.1 → XP_036013134.1 neurexin 3 isoform X16

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1403 → 1438

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_036157235.1 → XP_036013128.1 neurexin 3 isoform X9

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1480 → 1515

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_036157245.1 → XP_036013138.1 neurexin 3 isoform X21

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1373 → 1408

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_006515556.3 → XP_006515619.1 neurexin 3 isoform X3

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1501 → 1536

Syndecan; Syndecan domain

pfam02210
Location:903 → 1028

Laminin_G_2; Laminin G domain
XM_030246606.2 → XP_030102466.1 neurexin 3 isoform X18

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1394 → 1429

Syndecan; Syndecan domain

pfam02210
Location:903 → 1028

Laminin_G_2; Laminin G domain
XM_036157237.1 → XP_036013130.1 neurexin 3 isoform X11

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1471 → 1506

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_036157231.1 → XP_036013124.1 neurexin 3 isoform X4

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1501 → 1536

Syndecan; Syndecan domain

pfam02210
Location:894 → 1022

Laminin_G_2; Laminin G domain
XM_036157243.1 → XP_036013136.1 neurexin 3 isoform X19

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1394 → 1429

Syndecan; Syndecan domain

pfam02210
Location:894 → 1022

Laminin_G_2; Laminin G domain
XM_036157238.1 → XP_036013131.1 neurexin 3 isoform X12

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1471 → 1506

Syndecan; Syndecan domain

pfam02210
Location:894 → 1022

Laminin_G_2; Laminin G domain
XM_036157233.1 → XP_036013126.1 neurexin 3 isoform X7

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1492 → 1527

Syndecan; Syndecan domain

pfam02210
Location:894 → 1022

Laminin_G_2; Laminin G domain
XM_036157240.1 → XP_036013133.1 neurexin 3 isoform X15

UniProtKB/TrEMBL

E9Q2X2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 231

EGF; EGF-like domain

pfam01034
Location:1462 → 1497

Syndecan; Syndecan domain

pfam02210
Location:894 → 1022

Laminin_G_2; Laminin G domain