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    Zfp37 zinc finger protein 37 [ Mus musculus (house mouse) ]

    Gene ID: 22696, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp37provided by MGI
    Official Full Name
    zinc finger protein 37provided by MGI
    Primary source
    MGI:MGI:99181
    See related
    Ensembl:ENSMUSG00000028389 AllianceGenome:MGI:99181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tzn; Zfp-37
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within germ cell development. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; foregut; and genitourinary system. Orthologous to human ZFP37 (ZFP37 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 14.6), CNS E11.5 (RPKM 4.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B3; 4 33.04 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62107777..62126685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62189537..62209129, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12909 Neighboring gene STARR-seq mESC enhancer starr_10409 Neighboring gene major urinary protein 21 Neighboring gene STARR-seq mESC enhancer starr_10410 Neighboring gene STARR-seq mESC enhancer starr_10411 Neighboring gene STARR-seq mESC enhancer starr_10413 Neighboring gene STARR-seq mESC enhancer starr_10414 Neighboring gene predicted gene, 30511 Neighboring gene STARR-positive B cell enhancer ABC_E4633 Neighboring gene STARR-seq mESC enhancer starr_10417 Neighboring gene predicted gene, 23148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS. Mazarakis N, et al. Genomics, 1996 Apr 15. PMID 8660973
    2. Cloning and sequencing of a zinc finger cDNA expressed in mouse testis. Nelki D, et al. Nucleic Acids Res, 1990 Jun 25. PMID 2114017, Free PMC Article
    3. The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains. Payen E, et al. J Biol Chem, 1998 Apr 10. PMID 9535899
    4. Zfp-37, a new murine zinc finger encoding gene, is expressed in a developmentally regulated pattern in the male germ line. Burke PS, et al. Nucleic Acids Res, 1992 Jun 11. PMID 1614869, Free PMC Article
    5. Linkage analysis of the whirler deafness gene on mouse chromosome 4. Fleming J, et al. Genomics, 1994 May 1. PMID 8088814

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within germ cell development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 37
    Names
    male germ cell-specific zinc finger protein
    zinc finger protein 37 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290350.2 → NP_001277279.1  zinc finger protein 37 isoform 1

      See identical proteins and their annotated locations for NP_001277279.1

      Status: VALIDATED

      Source sequence(s)
      AL683829
      Consensus CDS
      CCDS71400.1
      UniProtKB/Swiss-Prot
      P17141, Q62514, Q80YX7
      Related
      ENSMUSP00000070463.4, ENSMUST00000068822.4
      Conserved Domains (6) summary
      cd07765
      Location:15 → 42
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:15 → 62
      KRAB; krueppel associated box
      COG5048
      Location:124 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:397 → 417
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:451 → 473
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:353 → 378
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001290351.2 → NP_001277280.1  zinc finger protein 37 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683829
      Consensus CDS
      CCDS89756.1
      UniProtKB/TrEMBL
      A0A1Y7VLM5
      Related
      ENSMUSP00000152266.2, ENSMUST00000221329.2
      Conserved Domains (6) summary
      cd07765
      Location:1 → 39
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:12 → 59
      KRAB; krueppel associated box
      COG5048
      Location:121 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:448 → 470
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:350 → 375
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001290353.2 → NP_001277282.1  zinc finger protein 37 isoform 4

      See identical proteins and their annotated locations for NP_001277282.1

      Status: VALIDATED

      Source sequence(s)
      AL683829
      Consensus CDS
      CCDS89754.1
      UniProtKB/TrEMBL
      A0A1Y7VJF3
      Related
      ENSMUSP00000152400.2, ENSMUST00000222748.2
      Conserved Domains (3) summary
      COG5048
      Location:83 → 445
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356 → 376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:509 → 533
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001348347.2 → NP_001335276.1  zinc finger protein 37 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL683829
      Consensus CDS
      CCDS89754.1
      UniProtKB/TrEMBL
      A0A1Y7VJF3
      Conserved Domains (3) summary
      COG5048
      Location:83 → 445
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356 → 376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:509 → 533
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001424895.1 → NP_001411824.1  zinc finger protein 37 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL683829

    6. NM_009554.5 → NP_033580.3  zinc finger protein 37 isoform 2

      See identical proteins and their annotated locations for NP_033580.3

      Status: VALIDATED

      Source sequence(s)
      AL683829
      Consensus CDS
      CCDS89755.1
      UniProtKB/TrEMBL
      Q6P3Z4
      Related
      ENSMUSP00000152491.2, ENSMUST00000222050.2
      Conserved Domains (6) summary
      cd07765
      Location:1 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:9 → 58
      KRAB; krueppel associated box
      COG5048
      Location:120 → 482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393 → 413
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:447 → 469
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:349 → 374
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_188978.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683829

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62107777..62126685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17141.4 GenPept UniProtKB/Swiss-Prot:P17141

    Gene LinkOut

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