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    Myh8 myosin, heavy polypeptide 8, skeletal muscle, perinatal [ Mus musculus (house mouse) ]

    Gene ID: 17885, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Myh8provided by MGI
    Official Full Name
    myosin, heavy polypeptide 8, skeletal muscle, perinatalprovided by MGI
    Primary source
    MGI:MGI:1339712
    See related
    Ensembl:ENSMUSG00000055775 AllianceGenome:MGI:1339712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MHCp; Myhsp; Myhs-p; MyHC-pn; 4832426G23Rik
    Summary
    This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 10.6), lung adult (RPKM 9.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 40.59 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67167950..67199460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67277124..67308634)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 1, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG) Neighboring gene STARR-seq mESC enhancer starr_29799 Neighboring gene myosin, heavy polypeptide 13, skeletal muscle Neighboring gene predicted gene, 40029 Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 31459

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression. Xing Y, et al. J Am Heart Assoc, 2023 Apr 4. PMID 36942752, Free PMC Article
    2. Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line. Cox RD, et al. Dev Biol, 1991 Jan. PMID 1985022
    3. Calpain-6 deficiency promotes skeletal muscle development and regeneration. Tonami K, et al. PLoS Genet, 2013. PMID 23935533, Free PMC Article
    4. Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development. Usami A, et al. Anat Histol Embryol, 2003 Aug. PMID 12919077
    5. Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle. Weydert A, et al. J Biol Chem, 1983 Nov 25. PMID 6196357

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
      Title: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4211

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-8
    Names
    Beta-MHC antisense
    myHC-perinatal
    myosin heavy chain 8
    myosin heavy chain, skeletal muscle, perinatal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177369.3 → NP_796343.2  myosin-8

      See identical proteins and their annotated locations for NP_796343.2

      Status: REVIEWED

      Source sequence(s)
      AL596129
      Consensus CDS
      CCDS24857.1
      UniProtKB/Swiss-Prot
      P13542, Q5SX36
      UniProtKB/TrEMBL
      B2RWW8
      Related
      ENSMUSP00000019625.6, ENSMUST00000019625.12
      Conserved Domains (6) summary
      cl22853
      Location:102 → 769
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:90 → 769
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:849 → 1926
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:38 → 75
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam06273
      Location:1042 → 1099
      eIF-4B; Plant specific eukaryotic initiation factor 4B
      cl19764
      Location:1375 → 1550
      COG6; Conserved oligomeric complex COG6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67167950..67199460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156398.1 → XP_036012291.1  myosin-8 isoform X1

      UniProtKB/TrEMBL
      B2RWW8
      Conserved Domains (3) summary
      pfam01576
      Location:849 → 1955
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:37 → 75
      Myosin_N; Myosin N-terminal SH3-like domain
      cl22853
      Location:102 → 769
      Motor_domain; Myosin and Kinesin motor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13542.2 GenPept UniProtKB/Swiss-Prot:P13542

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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