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    Bri3 brain protein I3 [ Mus musculus (house mouse) ]

    Gene ID: 55950, updated on 7-Apr-2024

    Summary

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    Official Symbol
    Bri3provided by MGI
    Official Full Name
    brain protein I3provided by MGI
    Primary source
    MGI:MGI:1933174
    See related
    Ensembl:ENSMUSG00000047843 AllianceGenome:MGI:1933174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I3; Gm38675
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Is expressed in pituitary gland. Orthologous to human BRI3 (brain protein I3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in stomach adult (RPKM 96.2), adrenal adult (RPKM 87.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5; 5 G2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144181247..144383567)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144244437..144264573)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2183 Neighboring gene RIKEN cDNA 2900089D17 gene Neighboring gene BAI1-associated protein 2-like 1 Neighboring gene predicted gene 15708 Neighboring gene STARR-seq mESC enhancer starr_14808 Neighboring gene Dmrt1 interacting ncRNA Neighboring gene STARR-seq mESC enhancer starr_14810 Neighboring gene predicted gene, 33552 Neighboring gene STARR-seq mESC enhancer starr_14811 Neighboring gene STARR-seq mESC enhancer starr_14813 Neighboring gene predicted gene, 33714 Neighboring gene predicted gene, 33765

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. Wu H, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592447
    2. A Collection of cDNA Clones with Specific Expression Patterns in Mouse Brain. Kato K. Eur J Neurosci, 1990. PMID 12106288
    3. Partial transcriptome of the developing pituitary gland. Douglas KR, et al. Genomics, 2000 Dec 15. PMID 11161784
    4. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane protein BRI3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163709.2 → NP_001157181.1  membrane protein BRI3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139636
      Consensus CDS
      CCDS51694.1
      UniProtKB/TrEMBL
      E9PUB2
      Related
      ENSMUSP00000106323.2, ENSMUST00000110695.8
      Conserved Domains (1) summary
      pfam10164
      Location:40 → 120
      DUF2367; Uncharacterized conserved protein (DUF2367)

    2. NM_018772.5 → NP_061242.3  membrane protein BRI3 isoform 1

      See identical proteins and their annotated locations for NP_061242.3

      Status: VALIDATED

      Source sequence(s)
      AC139636
      Consensus CDS
      CCDS19848.1
      UniProtKB/Swiss-Prot
      P28662, Q501N3, Q9Z1S1
      UniProtKB/TrEMBL
      Q8C4X5
      Related
      ENSMUSP00000057263.7, ENSMUST00000056578.7
      Conserved Domains (1) summary
      pfam10164
      Location:29 → 124
      DUF2367; Uncharacterized conserved protein (DUF2367)

    RNA

    1. NR_190571.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139636

    2. NR_190572.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134523, AC139636

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144181247..144383567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165318.1 → XP_036021211.1  membrane protein BRI3 isoform X1

      UniProtKB/TrEMBL
      Q8C7X8
      Conserved Domains (1) summary
      pfam10164
      Location:29 → 82
      DUF2367; Uncharacterized conserved protein (DUF2367)

    RNA

    1. XR_004942543.1 RNA Sequence

      Related
      ENSMUST00000155491.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28662.2 GenPept UniProtKB/Swiss-Prot:P28662

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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