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    Ptpre protein tyrosine phosphatase, receptor type, E [ Mus musculus (house mouse) ]

    Gene ID: 19267, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptpreprovided by MGI
    Official Full Name
    protein tyrosine phosphatase, receptor type, Eprovided by MGI
    Primary source
    MGI:MGI:97813
    See related
    Ensembl:ENSMUSG00000041836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PT; RP; PTPe; PTPepsilon; RPTPepsilon
    Expression
    Ubiquitous expression in lung adult (RPKM 7.9), thymus adult (RPKM 6.2) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ptpre in Genome Data Viewer
    Location:
    7 F3; 7 81.27 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (135139195..135288023)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (135537824..135686294)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (142729507..142877977)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36356 Neighboring gene clarin 3 Neighboring gene microRNA 1962 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene antigen identified by monoclonal antibody Ki 67 Neighboring gene predicted gene, 36431

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase epsilon
    Names
    R-PTP-epsilon
    protein-tyrosine phosphatase epsilon
    NP_001303607.1
    NP_001303608.1
    NP_001303609.1
    NP_001303610.1
    NP_035342.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316678.1NP_001303607.1  receptor-type tyrosine-protein phosphatase epsilon isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC123047, AK004602, AK132455, U40280
      Consensus CDS
      CCDS85444.1
      UniProtKB/Swiss-Prot
      P49446
      UniProtKB/TrEMBL
      A0A1B0GRT6, Q3V1H5
      Related
      ENSMUSP00000147656.2, ENSMUST00000209256.2
      Conserved Domains (2) summary
      smart00194
      Location:154412
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:180412
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_001316679.1NP_001303608.1  receptor-type tyrosine-protein phosphatase epsilon isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC123047, U40280
      Consensus CDS
      CCDS21944.1
      UniProtKB/Swiss-Prot
      P49446
      Related
      ENSMUSP00000147313.2, ENSMUST00000210833.2
      Conserved Domains (2) summary
      smart00194
      Location:134392
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:160392
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_001316680.1NP_001303609.1  receptor-type tyrosine-protein phosphatase epsilon isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC123047, AC151841, BC053408, U40280
      Consensus CDS
      CCDS85445.1
      UniProtKB/Swiss-Prot
      P49446
      UniProtKB/TrEMBL
      A0A1B0GRH2
      Related
      ENSMUSP00000147524.2, ENSMUST00000211788.2
      Conserved Domains (2) summary
      smart00194
      Location:147405
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:173405
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. NM_001316681.1NP_001303610.1  receptor-type tyrosine-protein phosphatase epsilon isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC123047, AK132455, BY210317, U40280
      Consensus CDS
      CCDS85446.1
      UniProtKB/Swiss-Prot
      P49446
      UniProtKB/TrEMBL
      Q3V1H5
      Related
      ENSMUSP00000147613.2, ENSMUST00000209979.2
      Conserved Domains (2) summary
      smart00194
      Location:77335
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:103335
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. NM_011212.3NP_035342.3  receptor-type tyrosine-protein phosphatase epsilon isoform b precursor

      See identical proteins and their annotated locations for NP_035342.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC123047, AC151838, AC151841
      Consensus CDS
      CCDS21944.1
      UniProtKB/Swiss-Prot
      P49446
      Related
      ENSMUSP00000073616.7, ENSMUST00000073961.8
      Conserved Domains (2) summary
      smart00194
      Location:134392
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:160392
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      135139195..135288023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001785494.3 RNA Sequence

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