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    Peg3 paternally expressed 3 [ Mus musculus (house mouse) ]

    Gene ID: 18616, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Peg3provided by MGI
    Official Full Name
    paternally expressed 3provided by MGI
    Primary source
    MGI:MGI:104748
    See related
    Ensembl:ENSMUSG00000002265 AllianceGenome:MGI:104748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pw1; End4; ASF-1; Gcap4; Zfp102; mKIAA0287
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in autophagosome and nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Orthologous to human PEG3 (paternally expressed 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 77.8), limb E14.5 (RPKM 49.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Peg3 in Genome Data Viewer
    Location:
    7 A1; 7 3.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6706891..6733443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6703892..6730462, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger, imprinted 2 Neighboring gene zinc finger, imprinted 1 Neighboring gene STARR-seq mESC enhancer starr_17985 Neighboring gene Peg3 opposite strand Neighboring gene ubiquitin specific peptidase 29 Neighboring gene Tctex1 domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17987 Neighboring gene STARR-seq mESC enhancer starr_17989 Neighboring gene microRNA 3099

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Allele-specific enhancer interaction at the Peg3 imprinted domain. Kim J, et al. PLoS One, 2019. PMID 31639176, Free PMC Article
    2. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. McNamara GI, et al. Hum Mol Genet, 2018 Feb 1. PMID 29186532, Free PMC Article
    3. Transcription-driven DNA methylation setting on the mouse Peg3 locus. Bretz CL, et al. Epigenetics, 2017. PMID 28925797, Free PMC Article
    4. Fibrogenic Potential of PW1/Peg3 Expressing Cardiac Stem Cells. Yaniz-Galende E, et al. J Am Coll Cardiol, 2017 Aug 8. PMID 28774379
    5. Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting. Patiño-Parrado I, et al. Nucleic Acids Res, 2017 Sep 6. PMID 28605464, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
      Title: Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
    2. Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.
      Title: Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.
    3. Allele-specific enhancer interaction at the Peg3 imprinted domain
      Title: Allele-specific enhancer interaction at the Peg3 imprinted domain.
    4. Study data show that Pw1/Peg3 regulates muscle fiber number determination during fetal development in a gene-dosage manner and regulates satellite cell metabolism in the adult.
      Title: The imprinted gene Pw1/Peg3 regulates skeletal muscle growth, satellite cell metabolic state, and self-renewal.
    5. Maternal deletion of Peg3-DMR (differentially methylated region) caused significant effects on the activity of the paternal allele, 2-fold increase of Peg3 and Usp29 throughout various tissues and different developmental stages. These effects were unidirectional with the maternal allele influencing the paternal one. These results suggest the presence of trans-allelic regulation associated with the Peg3-DMR.
      Title: Trans-allelic mutational effects at the Peg3 imprinted locus.
    6. YY1 is mainly involved in controlling the transcriptional levels, but not the DNA methylation, of the Peg3 domain.
      Title: YY1's role in the Peg3 imprinted domain.
    7. this study suggests that Peg3 may function as a direct transcriptional regulator for Oxtr expression that acts to moderate the milk letdown process.
      Title: Oxytocin receptor is regulated by Peg3.
    8. Data shows that loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers
      Title: Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers.
    9. Transcription driven by the alternative promoter U1 is required for oocyte-specific DNA methylation setting on the Peg3 locus.
      Title: Transcription-driven DNA methylation setting on the mouse Peg3 locus.
    10. The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both males and females, while the mutants with biallelic expression of Peg3 and Usp29 resulted in an increased growth rate of female mice only
      Title: Allele and dosage specificity of the Peg3 imprinted domain.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    paternally-expressed gene 3 protein
    Names
    granule cell antiserum positive 4
    paternally expressed gene 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417064.1 → NP_001403993.1  paternally-expressed gene 3 protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157657
      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

    2. NM_001417065.1 → NP_001403994.1  paternally-expressed gene 3 protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157657
      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

    3. NM_001417066.1 → NP_001403995.1  paternally-expressed gene 3 protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157657
      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

    4. NM_001417068.1 → NP_001403997.1  paternally-expressed gene 3 protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157657
      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

    5. NM_001417070.1 → NP_001403999.1  paternally-expressed gene 3 protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157657
      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

    6. NM_001417071.1 → NP_001404000.1  paternally-expressed gene 3 protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC157657

    7. NM_001417072.1 → NP_001404001.1  paternally-expressed gene 3 protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC157657

    8. NM_008817.3 → NP_032843.2  paternally-expressed gene 3 protein isoform a

      See identical proteins and their annotated locations for NP_032843.2

      Status: VALIDATED

      Source sequence(s)
      AC157657
      Consensus CDS
      CCDS20783.1
      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
      UniProtKB/TrEMBL
      A0A5F8MPW9
      Related
      ENSMUSP00000050750.5, ENSMUST00000051209.11
      Conserved Domains (3) summary
      PHA03169
      Location:862 → 1080
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1147 → 1169
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6706891..6733443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242211.2 → XP_030098071.1  paternally-expressed gene 3 protein isoform X3

      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
      UniProtKB/TrEMBL
      A0A5F8MPW9
      Conserved Domains (3) summary
      PHA03169
      Location:862 → 1080
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1147 → 1169
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_017322030.3 → XP_017177519.1  paternally-expressed gene 3 protein isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPW9
      Conserved Domains (3) summary
      PHA03169
      Location:943 → 1151
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1218 → 1240
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_036152771.1 → XP_036008664.1  paternally-expressed gene 3 protein isoform X3

      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
      UniProtKB/TrEMBL
      A0A5F8MPW9
      Conserved Domains (3) summary
      PHA03169
      Location:862 → 1080
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1147 → 1169
      zf-C2H2; Zinc finger, C2H2 type

    4. XM_036152776.1 → XP_036008669.1  paternally-expressed gene 3 protein isoform X4

      UniProtKB/TrEMBL
      Q0P5Y8
      Conserved Domains (3) summary
      PHA03169
      Location:718 → 936
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1003 → 1025
      zf-C2H2; Zinc finger, C2H2 type

    5. XM_030242212.1 → XP_030098072.1  paternally-expressed gene 3 protein isoform X3

      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
      UniProtKB/TrEMBL
      A0A5F8MPW9
      Conserved Domains (3) summary
      PHA03169
      Location:862 → 1080
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1147 → 1169
      zf-C2H2; Zinc finger, C2H2 type

    6. XM_036152774.1 → XP_036008667.1  paternally-expressed gene 3 protein isoform X3

      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
      UniProtKB/TrEMBL
      A0A5F8MPW9
      Conserved Domains (3) summary
      PHA03169
      Location:862 → 1080
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1147 → 1169
      zf-C2H2; Zinc finger, C2H2 type

    7. XM_036152773.1 → XP_036008666.1  paternally-expressed gene 3 protein isoform X3

      UniProtKB/Swiss-Prot
      O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
      UniProtKB/TrEMBL
      A0A5F8MPW9
      Conserved Domains (3) summary
      PHA03169
      Location:862 → 1080
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1147 → 1169
      zf-C2H2; Zinc finger, C2H2 type

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001010988.1: Suppressed sequence

      Description
      NM_001010988.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URU2.1 GenPept UniProtKB/Swiss-Prot:Q3URU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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