Zdhhc24 zinc finger, DHHC domain containing 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc24provided by MGI
Official Full Name: zinc finger, DHHC domain containing 24provided by MGI
Primary source: MGI:MGI:1917855
See related: Ensembl:ENSMUSG00000006463 AllianceGenome:MGI:1917855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Leng4; 5730496N17Rik
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; endocrine gland; genitourinary system; and spinal cord mantle layer. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 20.6), ovary adult (RPKM 13.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.13 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4928696..4935425)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4878668..4885397)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptidyl-L-cysteine S-palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable palmitoyltransferase ZDHHC24

Names: DHHC-24; leukocyte receptor cluster (LRC) member 4; zinc finger DHHC domain-containing protein 24

NP_001161988.1

EC 2.3.1.225

NP_001161989.1

EC 2.3.1.225

NP_081752.2

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168516.1 → NP_001161988.1 probable palmitoyltransferase ZDHHC24 isoform b

See identical proteins and their annotated locations for NP_001161988.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AC141437, CA559443, CD354313

UniProtKB/TrEMBL

Q3TA22

Related

ENSMUST00000162088.8
NM_001168517.1 → NP_001161989.1 probable palmitoyltransferase ZDHHC24 isoform b

See identical proteins and their annotated locations for NP_001161989.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AC141437

UniProtKB/TrEMBL

Q3TA22

Related

ENSMUST00000162134.2
NM_027476.3 → NP_081752.2 probable palmitoyltransferase ZDHHC24 isoform a

See identical proteins and their annotated locations for NP_081752.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC141437, AK171568

Consensus CDS

CCDS50353.1

UniProtKB/Swiss-Prot

Q3TAY4, Q3TDF1, Q3TF09, Q6IR37, Q9CS66

Related

ENSMUSP00000006632.8, ENSMUST00000006632.8

Conserved Domains (1) summary

pfam01529
Location:95 → 232

zf-DHHC; DHHC palmitoyltransferase