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    Hykk hydroxylysine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 235386, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hykkprovided by MGI
    Official Full Name
    hydroxylysine kinase 1provided by MGI
    Primary source
    MGI:MGI:2443139
    See related
    Ensembl:ENSMUSG00000035878 AllianceGenome:MGI:2443139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agphd1; C630028N24Rik
    Summary
    Predicted to enable hydroxylysine kinase activity. Predicted to be located in cytoplasm. Orthologous to human HYKK (hydroxylysine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 15.0), liver adult (RPKM 4.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 29.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54824574..54857208)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54917290..54949924)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24177 Neighboring gene STARR-seq mESC enhancer starr_24179 Neighboring gene STARR-positive B cell enhancer ABC_E2292 Neighboring gene iron responsive element binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1787 Neighboring gene STARR-positive B cell enhancer ABC_E6734 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome subunit alpha 4 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amino acid kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxylysine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxylysine kinase
    Names
    5-hydroxy-L-lysine kinase
    aminoglycoside phosphotransferase domain containing 1
    aminoglycoside phosphotransferase domain-containing protein 1
    NP_796325.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177351.4 → NP_796325.2  hydroxylysine kinase

      See identical proteins and their annotated locations for NP_796325.2

      Status: VALIDATED

      Source sequence(s)
      AC161264, AK162425
      Consensus CDS
      CCDS23197.1
      UniProtKB/Swiss-Prot
      Q3TQ48, Q3TRW8, Q3UU28, Q5U5V2, Q8C3L8
      Related
      ENSMUSP00000039980.8, ENSMUST00000039742.8
      Conserved Domains (2) summary
      COG2334
      Location:11 → 351
      SrkA; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]
      cl21453
      Location:33 → 311
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54824574..54857208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U5V2.2 GenPept UniProtKB/Swiss-Prot:Q5U5V2

    Gene LinkOut

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