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    Neil3 nei like 3 (E. coli) [ Mus musculus (house mouse) ]

    Gene ID: 234258, updated on 8-Jul-2021

    Summary

    Official Symbol
    Neil3provided by MGI
    Official Full Name
    nei like 3 (E. coli)provided by MGI
    Primary source
    MGI:MGI:2384588
    See related
    Ensembl:ENSMUSG00000039396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C85903; AI449477; BC034753
    Expression
    Biased expression in liver E14 (RPKM 18.3), liver E14.5 (RPKM 15.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Neil3 in Genome Data Viewer
    Location:
    8; 8 B1.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (54039902..54092100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (53586867..53639065, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (54672221..54724419, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene aspartylglucosaminidase Neighboring gene predicted gene, 39181 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized protein C12orf41 homolog Neighboring gene predicted gene, 33153 Neighboring gene vascular endothelial growth factor C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC27861, MGC36916

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA N-glycosylase activity TAS
    Traceable Author Statement
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables bubble DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endonuclease 8-like 3
    Names
    DNA glycosylase FPG2
    DNA glycosylase/AP lyase Neil3
    endonuclease VIII-like 3
    nei endonuclease VIII-like 3
    nei-like protein 3
    NP_666320.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146208.2NP_666320.1  endonuclease 8-like 3

      See identical proteins and their annotated locations for NP_666320.1

      Status: VALIDATED

      Source sequence(s)
      AC108413, AI510383, AK031027, BF714693, BF714694, DV646606
      Consensus CDS
      CCDS22305.1
      UniProtKB/Swiss-Prot
      Q8K203
      Related
      ENSMUSP00000041909.5, ENSMUST00000047768.11
      Conserved Domains (5) summary
      cd08969
      Location:1152
      MeNeil3_N; N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)
      sd00029
      Location:322341
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:318347
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam06831
      Location:182223
      H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
      pfam06839
      Location:506551
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      54039902..54092100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_870387.1 RNA Sequence

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