Neil3 nei like 3 (E. coli) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neil3provided by MGI
Official Full Name: nei like 3 (E. coli)provided by MGI
Primary source: MGI:MGI:2384588
See related: Ensembl:ENSMUSG00000039396 AllianceGenome:MGI:2384588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA binding activity and catalytic activity, acting on DNA. Involved in base-excision repair. Located in nucleus. Is expressed in several structures, including brain; retina nuclear layer; spinal cord; spleen; and testis. Orthologous to human NEIL3 (nei like DNA glycosylase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 18.3), liver E14.5 (RPKM 15.0) and 9 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8 B1.3; 8 29.14 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (54039902..54092100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (53586867..53639065, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
Title: WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway.
Title: NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway.
Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model.
Title: Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model.
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.
Title: NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.
Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.
Title: Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.
NEIL1 and NEIL3 may protect cells against cytotoxic and mutagenic effects of NM-Fapy-dG, but NEIL1 may have a unique role in initiation of base excision repair of AFB1-Fapy-dG
Title: Processing of N(5)-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
Results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage.
Title: Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Data suggest that neurogenesis induced by Neil3 repair of oxidative DNA damage protects against prion disease during the clinical phase.
Title: Neil3 induced neurogenesis protects against prion disease during the clinical phase.
NEIL3-dependent modulation of DNA methylation regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction.
Title: NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity.
Title: Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI449477 (e-PCR)
- UniSTS:179745

RH127240 (e-PCR)
- UniSTS:208282

Neil3 (e-PCR), detects polymorphism
- UniSTS:525732

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info
enables DNA N-glycosylase activity	TAS Traceable Author Statement more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	ISO Inferred from Sequence Orthology more info
enables bubble DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: endonuclease 8-like 3

Names: DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; endonuclease VIII-like 3; nei endonuclease VIII-like 3; nei-like protein 3

NP_666320.1

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146208.2 → NP_666320.1 endonuclease 8-like 3

See identical proteins and their annotated locations for NP_666320.1

Status: VALIDATED

Source sequence(s)

AC108413, AI510383, AK031027, BF714693, BF714694, DV646606

Consensus CDS

CCDS22305.1

UniProtKB/Swiss-Prot

Q4ADY6, Q8CD85, Q8K203, Q8R3P4

Related

ENSMUSP00000041909.5, ENSMUST00000047768.11

Conserved Domains (5) summary

cd08969
Location:1 → 152

MeNeil3_N; N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)

sd00029
Location:322 → 341

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:318 → 347

zf-RanBP; Zn-finger in Ran binding protein and others

pfam06831
Location:182 → 223

H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain

pfam06839
Location:506 → 551

zf-GRF; GRF zinc finger