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    Ing5 inhibitor of growth family, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 66262, updated on 10-Mar-2024

    Summary

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    Official Symbol
    Ing5provided by MGI
    Official Full Name
    inhibitor of growth family, member 5provided by MGI
    Primary source
    MGI:MGI:1922816
    See related
    Ensembl:ENSMUSG00000026283 AllianceGenome:MGI:1922816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700001C14Rik; 1700027H23Rik; 1810018M11Rik
    Summary
    Enables chromatin binding activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of apoptotic signaling pathway. Predicted to be located in chromosome. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in 1st branchial arch maxillary component; early conceptus; eye; and genitourinary system. Orthologous to human ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.0), CNS E11.5 (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 D; 1 47.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93731648..93749823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93803926..93822101)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95698432-95698719 Neighboring gene STARR-positive B cell enhancer ABC_E4338 Neighboring gene deoxythymidylate kinase Neighboring gene predicted gene, 22089 Neighboring gene STARR-positive B cell enhancer ABC_E7734 Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene STARR-seq mESC enhancer starr_01736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver. Mah SYY, et al. Front Immunol, 2023. PMID 37275850, Free PMC Article
    2. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway. Zhang GJ, et al. Biochem Biophys Res Commun, 2018 Feb 5. PMID 29326045
    3. Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells. Wang C, et al. Differentiation, 2020 Mar-Apr. PMID 31838455
    4. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One, 2011. PMID 21750715, Free PMC Article
    5. MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Voss AK, et al. Dev Cell, 2012 Sep 11. PMID 22921202, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
      Title: ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
    2. The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
      Title: The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
    3. Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.
      Title: Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.
    4. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway.
      Title: ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025454.2 → NP_079730.1  inhibitor of growth protein 5

      See identical proteins and their annotated locations for NP_079730.1

      Status: VALIDATED

      Source sequence(s)
      AK007536, AK028397, CAAA01224355
      Consensus CDS
      CCDS35673.1
      UniProtKB/Swiss-Prot
      Q3UL57, Q6P292, Q9CV64, Q9D8Y8, Q9D9V8
      Related
      ENSMUSP00000027505.7, ENSMUST00000027505.13
      Conserved Domains (2) summary
      cd15685
      Location:187 → 235
      PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
      pfam12998
      Location:6 → 105
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93731648..93749823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529792.4 → XP_006529855.1  inhibitor of growth protein 5 isoform X1

      Conserved Domains (2) summary
      cd15685
      Location:186 → 234
      PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
      cd16863
      Location:12 → 104
      ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029340.1: Suppressed sequence

      Description
      NM_029340.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8Y8.1 GenPept UniProtKB/Swiss-Prot:Q9D8Y8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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