Zbtb20 zinc finger and BTB domain containing 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb20provided by MGI
Official Full Name: zinc finger and BTB domain containing 20provided by MGI
Primary source: MGI:MGI:1929213
See related: Ensembl:ENSMUSG00000022708 AllianceGenome:MGI:1929213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HOF; J20; DPZF; Oda8; ODA-8S; Zfp288; D16Wsu73e; 1300017A20Rik; 7330412A13Rik; A930017C21Rik; Tg(PDGFB-APPSwInd)20Lms
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of glycolytic process; and regulation of gene expression. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ZBTB20 (zinc finger and BTB domain containing 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 5.3), heart adult (RPKM 4.7) and 26 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16 B4; 16 28.44 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (42728008..43462981)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (42875689..43634392)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
Title: ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
ZBTB20 is essential for cochlear maturation and hearing in mice.
Title: ZBTB20 is essential for cochlear maturation and hearing in mice.
ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.
Title: ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.
ZBTB20 regulates cardiac allograft rejection through NFsmall ka, CyrillicB-mediated inflammation in mouse heart transplantation.
Title: ZBTB20 regulates cardiac allograft rejection through NFкB-mediated inflammation in mouse heart transplantation.
Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.
Title: Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.
The zinc finger and BTB domain containing protein ZBTB20 regulates plasma triglyceride metabolism by repressing lipoprotein lipase gene transcription in hepatocytes.
Title: The zinc finger and BTB domain containing protein ZBTB20 regulates plasma triglyceride metabolism by repressing lipoprotein lipase gene transcription in hepatocytes.
An epigenetic circuit controls neurogenic programs during neocortex development.
Title: An epigenetic circuit controls neurogenic programs during neocortex development.
ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
Title: ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
Zinc Finger Protein ZBTB20 protects against cardiac remodelling post-myocardial infarction via ROS-TNFalpha/ASK1/JNK pathway regulation.
Title: Zinc Finger Protein ZBTB20 protects against cardiac remodelling post-myocardial infarction via ROS-TNFα/ASK1/JNK pathway regulation.
Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
Title: Zbtb20 deficiency causes cardiac contractile dysfunction in mice.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (5)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH125892 (e-PCR)
- UniSTS:142098

ZBTB20_9462 (e-PCR)
- UniSTS:468799

D16Mit213 (e-PCR), detects polymorphism
- UniSTS:127848

D16Mit39 (e-PCR), detects polymorphism
- UniSTS:127876

Results_ER_9_1_95_2_29.seq (e-PCR)
- UniSTS:125589

RH136622 (e-PCR)
- UniSTS:210602

Zbtb20 (e-PCR), detects polymorphism
- UniSTS:507335

41.MHAa90h5.seq (e-PCR)
- UniSTS:124393

fc31d07.x1 (e-PCR)
- UniSTS:193517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: zinc finger and BTB domain-containing protein 20

Names: APP Tg; BTB/POZ domain zinc finger factor HOF; PDGF-APPSwInd; PDGF-hAPP695,751,770V171F, KM670/671NL; POZ/zinc finger transcription factor ODA-8; zinc finger protein 288

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285805.1 → NP_001272734.1 zinc finger and BTB domain-containing protein 20 isoform L

See identical proteins and their annotated locations for NP_001272734.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variant 1 and 3 encode the same isoform (L).

Source sequence(s)

BC056446, BI659024

Consensus CDS

CCDS28178.1

UniProtKB/Swiss-Prot

A6X916, Q8K0L9, Q9DBD4, Q9QZ87

UniProtKB/TrEMBL

Q9QZF3

Conserved Domains (5) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18208
Location:79 → 195

BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)

pfam00096
Location:634 → 656

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:648 → 673

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:608 → 657

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
NM_001393397.1 → NP_001380326.1 zinc finger and BTB domain-containing protein 20 isoform L

Status: VALIDATED

Source sequence(s)

AC120871, CT010512, CT010517

UniProtKB/Swiss-Prot

A6X916, Q8K0L9, Q9DBD4, Q9QZ87

UniProtKB/TrEMBL

Q9QZF3

Related

ENSMUSP00000110342.3, ENSMUST00000114694.9

Conserved Domains (5) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18208
Location:79 → 195

BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)

pfam00096
Location:634 → 656

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:648 → 673

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:608 → 657

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
NM_001393398.1 → NP_001380327.1 zinc finger and BTB domain-containing protein 20 isoform L

Status: VALIDATED

Source sequence(s)

AC120871, CT010512, CT010517

UniProtKB/Swiss-Prot

A6X916, Q8K0L9, Q9DBD4, Q9QZ87

UniProtKB/TrEMBL

Q9QZF3

Conserved Domains (5) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18208
Location:79 → 195

BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)

pfam00096
Location:634 → 656

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:648 → 673

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:608 → 657

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
NM_001393399.1 → NP_001380328.1 zinc finger and BTB domain-containing protein 20 isoform S

Status: VALIDATED

Source sequence(s)

AC120871, CT010512, CT010517

UniProtKB/TrEMBL

Q9QZF3

Conserved Domains (6) summary

COG5048
Location:432 → 574

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:507 → 527

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18208
Location:6 → 122

BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)

pfam00096
Location:561 → 583

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:575 → 600

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:535 → 584

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
NM_019778.2 → NP_062752.2 zinc finger and BTB domain-containing protein 20 isoform L

See identical proteins and their annotated locations for NP_062752.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (L).

Source sequence(s)

AK005028, BC056446

Consensus CDS

CCDS28178.1

UniProtKB/Swiss-Prot

A6X916, Q8K0L9, Q9DBD4, Q9QZ87

UniProtKB/TrEMBL

Q9QZF3

Related

ENSMUSP00000078410.7, ENSMUST00000079441.13

Conserved Domains (5) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18208
Location:79 → 195

BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)

pfam00096
Location:634 → 656

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:648 → 673

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:608 → 657

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
NM_181058.1 → NP_851401.1 zinc finger and BTB domain-containing protein 20 isoform S

See identical proteins and their annotated locations for NP_851401.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate 5' UTR exon and the alternate exon containing the translation start site compared to variant 1. The resulting isoform (S) is shorter at the N-terminus compared to isoform L.

Source sequence(s)

AK005028, BC056446

Consensus CDS

CCDS49851.1

UniProtKB/TrEMBL

Q9QZF3

Related

ENSMUSP00000110339.2, ENSMUST00000114691.8

Conserved Domains (6) summary

COG5048
Location:432 → 574

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:507 → 527

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18208
Location:6 → 122

BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)

pfam00096
Location:561 → 583

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:575 → 600

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:535 → 584

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins