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    Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Mus musculus (house mouse) ]

    Gene ID: 22195, updated on 8-May-2024

    Summary

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    Official Symbol
    Ube2l3provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2L 3provided by MGI
    Primary source
    MGI:MGI:109240
    See related
    Ensembl:ENSMUSG00000038965 AllianceGenome:MGI:109240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UbcM4; Ubce7
    Summary
    Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; heart; immune system; lung; and reproductive system. Orthologous to human UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 45.0), liver E14 (RPKM 37.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 10.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16969879..17019363, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17152015..17201512, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rps20 pseudogene Neighboring gene coiled-coil domain containing 116 Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129 Neighboring gene RIMS binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin. Peris-Moreno D, et al. Cells, 2021 Aug 3. PMID 34440743, Free PMC Article
    2. The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes. Eldridge MJG, et al. Cell Rep, 2017 Jan 31. PMID 28147281, Free PMC Article
    3. Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4. Moynihan TP, et al. Mamm Genome, 1999 Oct. PMID 10501966
    4. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Harbers K, et al. Proc Natl Acad Sci U S A, 1996 Oct 29. PMID 8901595, Free PMC Article
    5. A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. Robinson PA, et al. Mamm Genome, 1995 Oct. PMID 8563171

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-1beta turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation.
      Title: IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation.
    2. UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.
      Title: UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.
    3. UBE2L3 depletion increases pro-IL-1beta levels.
      Title: The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transgenic (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118100

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 L3
    Names
    E2 ubiquitin-conjugating enzyme L3
    ubiquitin carrier protein L3
    ubiquitin-conjugating enzyme 7
    ubiquitin-protein ligase L3
    NP_001406151.1
    NP_001406152.1
    NP_001406153.1
    NP_001406154.1
    NP_001406155.1
    NP_001406156.1
    NP_001406158.1
    NP_033482.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419222.1 → NP_001406151.1  ubiquitin-conjugating enzyme E2 L3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154667

    2. NM_001419223.1 → NP_001406152.1  ubiquitin-conjugating enzyme E2 L3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Related
      ENSMUSP00000156283.2, ENSMUST00000232668.2

    3. NM_001419224.1 → NP_001406153.1  ubiquitin-conjugating enzyme E2 L3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154667

    4. NM_001419225.1 → NP_001406154.1  ubiquitin-conjugating enzyme E2 L3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154667

    5. NM_001419226.1 → NP_001406155.1  ubiquitin-conjugating enzyme E2 L3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154667
      UniProtKB/TrEMBL
      A0A338P7E5
      Related
      ENSMUSP00000156336.2, ENSMUST00000231643.2

    6. NM_001419227.1 → NP_001406156.1  ubiquitin-conjugating enzyme E2 L3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154667

    7. NM_001419229.1 → NP_001406158.1  ubiquitin-conjugating enzyme E2 L3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Related
      ENSMUSP00000156034.2, ENSMUST00000232035.2

    8. NM_009456.3 → NP_033482.1  ubiquitin-conjugating enzyme E2 L3 isoform 1

      See identical proteins and their annotated locations for NP_033482.1

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Consensus CDS
      CCDS27997.1
      UniProtKB/Swiss-Prot
      P68037
      UniProtKB/TrEMBL
      Q3TIH9, Q561N4
      Related
      ENSMUSP00000087658.6, ENSMUST00000090192.12
      Conserved Domains (1) summary
      smart00212
      Location:6 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RNA

    1. NR_185043.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667

    2. NR_185044.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667

    3. NR_185045.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667

    4. NR_185046.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667

    5. NR_185047.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154667

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16969879..17019363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68037.1 GenPept UniProtKB/Swiss-Prot:P68037

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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