Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc23a2provided by MGI
Official Full Name: solute carrier family 23 (nucleobase transporters), member 2provided by MGI
Primary source: MGI:MGI:1859682
See related: Ensembl:ENSMUSG00000027340 AllianceGenome:MGI:1859682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NBTL1; SVCT2; YSPL2; YSPL3; Slc23a1; mKIAA0238
Summary: Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Located in basal plasma membrane and cytoplasm. Is expressed in adrenal gland; central nervous system; metanephros; and retina. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 24.3), cortex adult (RPKM 20.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F2; 2 64.15 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (131894416..131987287, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (132052496..132145320, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages.
Title: Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages.
Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model.
Title: Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model.
SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.
Title: SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.
Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake.
Title: Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake.
Sodium vitamin C transporter 2 orchestrates lactate metabolism in mouse Sertoli cells.
Title: Sodium vitamin C transporter 2 orchestrates lactate metabolism in mouse Sertoli cells.
Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease.
Title: Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease.
SVCT2-Dependent plasma and mitochondrial membrane transport of ascorbic acid in differentiating myoblasts.
Title: SVCT2-Dependent plasma and mitochondrial membrane transport of ascorbic acid in differentiating myoblasts.
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions.
Title: Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions.
Alternative pathways and key genes that connect Tet2, Bcl2, and Slc23a2 for their therapeutic applications with vitamin C were identified.
Title: Association of Leukemia Target Genes Tet2, Bcl2, and Slc23a2 in Vitamin C Pathways.
The presence of alphaTTP and SVCT2 in brain regions implicated in learning, memory and motor control provides an anatomical basis that may explain the higher resistance of this animal model to brain oxidative stress, which is associated with better motor performance and learning abilities in old age.
Title: Vitamin transporters in mice brain with aging.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI844736 (e-PCR)
- UniSTS:165210

Slc23a2 (e-PCR), detects polymorphism
- UniSTS:547025

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-ascorbate:sodium symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-ascorbate:sodium symporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ascorbic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-ascorbic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carboxylic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monosaccharide transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 23 member 2

Names: Na(+)/L-ascorbic acid transporter 2; SVCT-2; mSVCT2; sodium-dependent vitamin C transporter 2; solute carrier family 23 (nucleobase transporters), member 1; yolk sac permease-like molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355430.2 → NP_001342359.1 solute carrier family 23 member 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).

Source sequence(s)

AL831706, AL929513

Consensus CDS

CCDS16769.1

UniProtKB/Swiss-Prot

Q80Y23, Q8C327, Q9EPR4, Q9JM78

Conserved Domains (1) summary

pfam00860
Location:103 → 529

Xan_ur_permease; Permease family
NM_001355431.2 → NP_001342360.1 solute carrier family 23 member 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AL831706

Related

ENSMUST00000127724.8

Conserved Domains (1) summary

cl23746
Location:86 → 156

HCO3_cotransp; HCO3- transporter family
NM_001421503.1 → NP_001408432.1 solute carrier family 23 member 2 isoform a

Status: VALIDATED

Source sequence(s)

AL831706, AL929513

UniProtKB/Swiss-Prot

Q80Y23, Q8C327, Q9EPR4, Q9JM78
NM_001421504.1 → NP_001408433.1 solute carrier family 23 member 2 isoform c

Status: VALIDATED

Source sequence(s)

AL831706, AL929513
NM_001421505.1 → NP_001408434.1 solute carrier family 23 member 2 isoform d

Status: VALIDATED

Source sequence(s)

AL831706
NM_001421507.1 → NP_001408436.1 solute carrier family 23 member 2 isoform e

Status: VALIDATED

Source sequence(s)

AL831706
NM_001421508.1 → NP_001408437.1 solute carrier family 23 member 2 isoform f

Status: VALIDATED

Source sequence(s)

AL831706
NM_018824.3 → NP_061294.2 solute carrier family 23 member 2 isoform a

See identical proteins and their annotated locations for NP_061294.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).

Source sequence(s)

AL831706, AL929513

Consensus CDS

CCDS16769.1

UniProtKB/Swiss-Prot

Q80Y23, Q8C327, Q9EPR4, Q9JM78

Related

ENSMUSP00000028815.9, ENSMUST00000028815.15

Conserved Domains (1) summary

pfam00860
Location:103 → 529

Xan_ur_permease; Permease family