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    Cab39 calcium binding protein 39 [ Mus musculus (house mouse) ]

    Gene ID: 12283, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Cab39provided by MGI
    Official Full Name
    calcium binding protein 39provided by MGI
    Primary source
    MGI:MGI:107438
    See related
    Ensembl:ENSMUSG00000036707 AllianceGenome:MGI:107438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MO25; MO25alpha
    Summary
    Predicted to enable calcium ion binding activity; kinase binding activity; and protein serine/threonine kinase activator activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and membrane. Predicted to be part of protein-containing complex. Predicted to colocalize with Z disc. Is expressed in several structures, including clavicle; cranial ganglion; dorsal root ganglion; neural retina; and secondary oocyte. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 37.9), colon adult (RPKM 29.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C5; 1 43.94 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85707796..85779298)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85793441..85851577)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630001G21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87629249-87629446 Neighboring gene STARR-positive B cell enhancer ABC_E1551 Neighboring gene STARR-positive B cell enhancer ABC_E1999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87647325-87647478 Neighboring gene STARR-seq mESC enhancer starr_01553 Neighboring gene microRNA 8096 Neighboring gene RIKEN cDNA 9930111H07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87690750-87690933 Neighboring gene STARR-positive B cell enhancer ABC_E3285 Neighboring gene STARR-seq mESC enhancer starr_01556 Neighboring gene integral membrane protein 2C Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis. Liu Q, et al. Bioengineered, 2022 Apr. PMID 35412939, Free PMC Article
    2. Molecular cloning of a novel mRNA sequence expressed in cleavage stage mouse embryos. Miyamoto H, et al. Mol Reprod Dev, 1993 Jan. PMID 8418809
    3. miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia. Fang X, et al. Haematologica, 2018 Mar. PMID 29269522, Free PMC Article
    4. Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25. Chen H, et al. PLoS One, 2012. PMID 22844503, Free PMC Article
    5. Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle. Smith CD, et al. J Appl Physiol (1985), 2011 Dec. PMID 21903876, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis.
      Title: Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis.
    2. miR-144/451 facilitates recovery from acute anemia by repressing Cab39/AMPK/mTOR
      Title: miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia.
    3. Cab39 differentially interacts with WNK4 and SPAK/OSR1 to switch the classic two kinase cascade into a signal kinase transduction
      Title: A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.
    4. Elevated miR-195 targets the LKB1/AMPK signaling axis in hypertrophic cardiomyopathy
      Title: Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25.
    5. Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle.
      Title: Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of serine/threonine protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 39
    Names
    calcium binding protein, 39 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355046.2 → NP_001341975.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      Consensus CDS
      CCDS15112.1
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8
      Conserved Domains (1) summary
      pfam08569
      Location:5 → 334
      Mo25; Mo25-like

    2. NM_001355047.2 → NP_001341976.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      Consensus CDS
      CCDS15112.1
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8
      Conserved Domains (1) summary
      pfam08569
      Location:5 → 334
      Mo25; Mo25-like

    3. NM_001420006.1 → NP_001406935.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    4. NM_001420007.1 → NP_001406936.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    5. NM_001420009.1 → NP_001406938.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    6. NM_001420010.1 → NP_001406939.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    7. NM_001420011.1 → NP_001406940.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    8. NM_001420012.1 → NP_001406941.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    9. NM_001420013.1 → NP_001406942.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    10. NM_001420014.1 → NP_001406943.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    11. NM_001420015.1 → NP_001406944.1  calcium-binding protein 39 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8

    12. NM_001420016.1 → NP_001406945.1  calcium-binding protein 39 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    13. NM_001420017.1 → NP_001406946.1  calcium-binding protein 39 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    14. NM_001420018.1 → NP_001406947.1  calcium-binding protein 39 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    15. NM_001420019.1 → NP_001406948.1  calcium-binding protein 39 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    16. NM_001420020.1 → NP_001406949.1  calcium-binding protein 39 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    17. NM_001420021.1 → NP_001406950.1  calcium-binding protein 39 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    18. NM_001420022.1 → NP_001406951.1  calcium-binding protein 39 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342

    19. NM_133781.6 → NP_598542.3  calcium-binding protein 39 isoform 1

      See identical proteins and their annotated locations for NP_598542.3

      Status: VALIDATED

      Source sequence(s)
      AC107707, AC161342
      Consensus CDS
      CCDS15112.1
      UniProtKB/Swiss-Prot
      Q06138, Q8VDZ8
      Related
      ENSMUSP00000108987.2, ENSMUST00000113360.8
      Conserved Domains (1) summary
      pfam08569
      Location:5 → 334
      Mo25; Mo25-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85707796..85779298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06138.2 GenPept UniProtKB/Swiss-Prot:Q06138

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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