Plau plasminogen activator, urokinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plauprovided by MGI
Official Full Name: plasminogen activator, urokinaseprovided by MGI
Primary source: MGI:MGI:97611
See related: Ensembl:ENSMUSG00000021822 AllianceGenome:MGI:97611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: uPA; u-PA
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to be located in cell surface and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 100.9), bladder adult (RPKM 27.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.53 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20886730..20893456)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20836662..20843388)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased fertility in female mice lacking urokinase plasminogen activator.
Title: Decreased fertility in female mice lacking urokinase plasminogen activator.
Urokinase-type plasminogen activator promotes corneal epithelial migration and nerve regeneration.
Title: Urokinase-type plasminogen activator promotes corneal epithelial migration and nerve regeneration.
Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44(+)-ENaC signal cascade.
Title: Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44(+)-ENaC signal cascade.
BMP2 downregulates urokinase-type plasminogen activator via p38 MAPK: Implications in C2C12 cells myogenic differentiation.
Title: BMP2 downregulates urokinase-type plasminogen activator via p38 MAPK: Implications in C2C12 cells myogenic differentiation.
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation.
Title: The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation.
GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Title: GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Title: PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.
Title: Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.
The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model.
Title: The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model.
upregulation of uPA does not alter lung inflammation but is associated with improved epithelial cell homeostasis in a mouse model of lung fibrosis
Title: Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491267

Plau (e-PCR), detects polymorphism
- UniSTS:507149

Plau (e-PCR), detects polymorphism
- UniSTS:238146

X02389 (e-PCR)
- UniSTS:125779

Plau (e-PCR), detects polymorphism
- UniSTS:144215

Plau (e-PCR), detects polymorphism
- UniSTS:144216

Plau (e-PCR), detects polymorphism
- UniSTS:144217

Plau (e-PCR), detects polymorphism
- UniSTS:525932

D14Nds1 (e-PCR), detects polymorphism
- UniSTS:141990

X02389 (e-PCR)
- UniSTS:163548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in fibrinolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibrinolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibrinolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of plasminogen activation	NAS Non-traceable Author Statement more info	PubMed
involved_in plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of fibrinolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasminogen activation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urokinase plasminogen activator signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info
part_of serine-type endopeptidase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: urokinase-type plasminogen activator

Names: U-plasminogen activator

NP_032899.1

EC 3.4.21.73

XP_017171408.1

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008873.3 → NP_032899.1 urokinase-type plasminogen activator precursor

See identical proteins and their annotated locations for NP_032899.1

Status: VALIDATED

Source sequence(s)

BY320655, X02389

Consensus CDS

CCDS26858.1

UniProtKB/Swiss-Prot

P06869

UniProtKB/TrEMBL

Q0VBA8

Related

ENSMUSP00000022368.3, ENSMUST00000022368.4

Conserved Domains (2) summary

cd00190
Location:180 → 424

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:71 → 152

Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

20886730..20893456

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315919.3 → XP_017171408.1 urokinase-type plasminogen activator isoform X1

UniProtKB/Swiss-Prot

P06869

UniProtKB/TrEMBL

Q0VBA8

Conserved Domains (2) summary

cd00190
Location:180 → 424

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:71 → 152

Kringle; Kringle domain