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    Tecpr1 tectonin beta-propeller repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70381, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tecpr1provided by MGI
    Official Full Name
    tectonin beta-propeller repeat containing 1provided by MGI
    Primary source
    MGI:MGI:1917631
    See related
    Ensembl:ENSMUSG00000066621 AllianceGenome:MGI:1917631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1358; 2210010N04Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagosome maturation. Predicted to be located in nucleoplasm. Predicted to be active in autophagosome membrane and lysosomal membrane. Is expressed in several structures, including alimentary system; brain; cochlea; ganglia; and vibrissa follicle. Orthologous to human TECPR1 (tectonin beta-propeller repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 45.0), thymus adult (RPKM 42.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 83.07 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144131260..144160433, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144194442..144223615, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:144923715-144923898 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene STARR-positive B cell enhancer ABC_E2183 Neighboring gene RIKEN cDNA 2900089D17 gene Neighboring gene brain protein I3 Neighboring gene BAI1-associated protein 2-like 1 Neighboring gene predicted gene 15708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Ogawa M, et al. Cell Host Microbe, 2011 May 19. PMID 21575909
    2. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners. Kim JH, et al. Autophagy, 2015. PMID 25484072, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    4. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article
    5. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tectonin beta-propeller repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356992.1 → NP_001343921.1  tectonin beta-propeller repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC139636
      Conserved Domains (5) summary
      smart00694
      Location:369 → 402
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:297 → 358
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:242 → 275
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:85 → 205
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam19193
      Location:431 → 573
      Tectonin; Tectonin domain

    2. NM_001356993.1 → NP_001343922.1  tectonin beta-propeller repeat-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AC139636
      Conserved Domains (5) summary
      smart00694
      Location:364 → 397
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:292 → 353
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:545 → 570
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:80 → 200
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam06462
      Location:522 → 550
      Hyd_WA; Propeller

    3. NM_027410.2 → NP_081686.1  tectonin beta-propeller repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC139636, AK040462, AW048569, BC046968
      Consensus CDS
      CCDS39377.1
      UniProtKB/Swiss-Prot
      Q80VP0, Q8CHA3, Q8R3E0, Q99KQ5, Q9CVC6
      Related
      ENSMUSP00000082844.7, ENSMUST00000085701.7
      Conserved Domains (6) summary
      smart00694
      Location:893 → 926
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:64 → 125
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:234 → 270
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:609 → 729
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:615 → 721
      PH; PH domain
      pfam06462
      Location:303 → 331
      Hyd_WA; Propeller

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144131260..144160433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504864.5 → XP_006504927.1  tectonin beta-propeller repeat-containing protein 1 isoform X1

      Conserved Domains (5) summary
      smart00694
      Location:762 → 795
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:690 → 751
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:103 → 139
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:478 → 598
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam06462
      Location:171 → 200
      Hyd_WA; Propeller

    2. XM_036165488.1 → XP_036021381.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

      Conserved Domains (5) summary
      smart00694
      Location:369 → 402
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:297 → 358
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:242 → 275
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:85 → 205
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam19193
      Location:431 → 573
      Tectonin; Tectonin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VP0.1 GenPept UniProtKB/Swiss-Prot:Q80VP0

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