Acaca acetyl-Coenzyme A carboxylase alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acacaprovided by MGI
Official Full Name: acetyl-Coenzyme A carboxylase alphaprovided by MGI
Primary source: MGI:MGI:108451
See related: Ensembl:ENSMUSG00000020532 AllianceGenome:MGI:108451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acac; Acc1; Gm738; A530025K05Rik
Summary: Enables acetyl-CoA carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.29 cM

Exon count:: 60

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (84020461..84292477)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (84129635..84401651)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARalpha- CPT1A axis.
Title: ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis.
Involvement of ACACA (acetyl-CoA carboxylase alpha) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
Title: Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.
Title: Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
Title: Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
Title: ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
Title: Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis.
Title: ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis.
Inhibition of ACC1 can be a previously unrecognized mechanism that underlies calorie restriction-afforded neuroprotection against cerebral ischemic stroke
Title: ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke.
Using mice with Ser(79)Ala/Ser(212)Ala knock-in mutations (ACC DKI) the authors find that inhibition of ACC phosphorylation leads to reduced appetite in response to fasting or cold exposure.
Title: AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.
AMPK-ACC signaling is coupled to the control of thrombosis by specifically modulating thromboxane and granule release in response to collagen.
Title: AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (8) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1255 (e-PCR)
- UniSTS:149800

NoName (e-PCR)
- UniSTS:224569

Acac (e-PCR), detects polymorphism
- UniSTS:461900

Acaca (e-PCR), detects polymorphism
- UniSTS:527229

NoName (e-PCR)
- UniSTS:236677

Acaca (e-PCR), detects polymorphism
- UniSTS:516497

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA carboxylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables acetyl-CoA carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetyl-CoA carboxylase activity	ISO Inferred from Sequence Orthology more info
enables biotin binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to prostaglandin E stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IGI Inferred from Genetic Interaction more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acetyl-CoA carboxylase 1

Names: ACC-alpha; acetyl-CoA carboxylase 265

NP_579938.2

EC 6.4.1.2

XP_006532016.1

EC 6.4.1.2

XP_006532017.1

EC 6.4.1.2

XP_006532018.1

EC 6.4.1.2

XP_006532019.1

EC 6.4.1.2

XP_011246968.2

EC 6.4.1.2

XP_011246969.1

EC 6.4.1.2

XP_030101321.1

EC 6.4.1.2

XP_030101322.1

EC 6.4.1.2

XP_030101323.1

EC 6.4.1.2

XP_036012108.1

EC 6.4.1.2

XP_036012109.1

EC 6.4.1.2

XP_036012110.1

EC 6.4.1.2

XP_036012111.1

EC 6.4.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133360.3 → NP_579938.2 acetyl-CoA carboxylase 1

See identical proteins and their annotated locations for NP_579938.2

Status: VALIDATED

Source sequence(s)

AL596252, AL596447

Consensus CDS

CCDS25185.1

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

84020461..84292477

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248667.2 → XP_011246969.1 acetyl-CoA carboxylase 1 isoform X4

See identical proteins and their annotated locations for XP_011246969.1

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_030245463.1 → XP_030101323.1 acetyl-CoA carboxylase 1 isoform X5

Conserved Domains (5) summary

COG0439
Location:1 → 450

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:501 → 648

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:583 → 648

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1499 → 2047

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:650 → 1399

ACC_central; Acetyl-CoA carboxylase, central region
XM_006531953.3 → XP_006532016.1 acetyl-CoA carboxylase 1 isoform X3

UniProtKB/Swiss-Prot

Q5SWU9

Conserved Domains (5) summary

COG0439
Location:155 → 657

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:708 → 855

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:791 → 855

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1706 → 2254

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:857 → 1606

ACC_central; Acetyl-CoA carboxylase, central region
XM_036156216.1 → XP_036012109.1 acetyl-CoA carboxylase 1 isoform X4

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_036156215.1 → XP_036012108.1 acetyl-CoA carboxylase 1 isoform X4

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_006531954.3 → XP_006532017.1 acetyl-CoA carboxylase 1 isoform X4

See identical proteins and their annotated locations for XP_006532017.1

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Related

ENSMUSP00000099490.2, ENSMUST00000103201.8

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_006531956.3 → XP_006532019.1 acetyl-CoA carboxylase 1 isoform X4

See identical proteins and their annotated locations for XP_006532019.1

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Related

ENSMUSP00000020843.7, ENSMUST00000020843.13

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_036156217.1 → XP_036012110.1 acetyl-CoA carboxylase 1 isoform X5

Conserved Domains (5) summary

COG0439
Location:1 → 450

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:501 → 648

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:583 → 648

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1499 → 2047

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:650 → 1399

ACC_central; Acetyl-CoA carboxylase, central region
XM_030245461.2 → XP_030101321.1 acetyl-CoA carboxylase 1 isoform X1

Conserved Domains (5) summary

COG0439
Location:195 → 697

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:748 → 895

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:831 → 895

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1746 → 2294

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:897 → 1646

ACC_central; Acetyl-CoA carboxylase, central region
XM_011248666.3 → XP_011246968.2 acetyl-CoA carboxylase 1 isoform X2

Conserved Domains (5) summary

COG0439
Location:195 → 697

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:748 → 895

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:831 → 895

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1738 → 2286

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:897 → 1638

ACC_central; Acetyl-CoA carboxylase, central region
XM_006531955.3 → XP_006532018.1 acetyl-CoA carboxylase 1 isoform X4

See identical proteins and their annotated locations for XP_006532018.1

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_036156218.1 → XP_036012111.1 acetyl-CoA carboxylase 1 isoform X5

Conserved Domains (5) summary

COG0439
Location:1 → 450

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:501 → 648

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:583 → 648

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1499 → 2047

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:650 → 1399

ACC_central; Acetyl-CoA carboxylase, central region
XM_030245462.2 → XP_030101322.1 acetyl-CoA carboxylase 1 isoform X4

UniProtKB/Swiss-Prot

A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region