Angptl6 angiopoietin-like 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angptl6provided by MGI
Official Full Name: angiopoietin-like 6provided by MGI
Primary source: MGI:MGI:1917976
See related: Ensembl:ENSMUSG00000038742 AllianceGenome:MGI:1917976
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AGF; ARP3; Arp5; 6330404E11Rik
Summary: Predicted to enable signaling receptor binding activity. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in secretory granule. Is expressed in brain. Used to study obesity. Orthologous to human ANGPTL6 (angiopoietin like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 15.9), placenta adult (RPKM 7.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.66 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20785104..20791116, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (20873808..20879822, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Arp5 expression by alternative splicing coupled to nonsense-mediated RNA decay.
Title: Regulation of Arp5 expression by alternative splicing coupled to nonsense-mediated RNA decay.
Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus.
Title: Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus.
Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin levels and hepatic Angptl6 expression.
Title: Leptin regulates the expression of angiopoietin-like 6.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Title: Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 production in adipose tissue and cultured adipocytes.
Title: ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21.
In addition to pronounced angiogenesis and epidermal hyperplasia, marked enlargement of dermal lymphatic vessels was observed in UV-B-exposed Angptl6/AGF transgenic mice.
Title: Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B.
Activation of an ERK1/2-eNOS-NO pathway is a crucial signaling mechanism by which angiopoietin-related growth factor increases blood flow through induction of angiogenesis and arteriogenesis.
Title: Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.
we show that (>80%) of the AGF-deficient mice die at about embryonic day 13, while the surviving AGF-deficient mice develop marked obesity, lipid accumulation in skeletal muscle and liver, and insulin resistance accompanied by reduced energy expenditure
Title: Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism.
Title: Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

06.MMHAP65FRB9.seq (e-PCR)
- UniSTS:122863

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: angiopoietin-related protein 6

Names: Angiopoietin-related growth factor; angiopoietin-like protein 6; angiopoietin-related protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145154.2 → NP_660136.1 angiopoietin-related protein 6 precursor

See identical proteins and their annotated locations for NP_660136.1

Status: PROVISIONAL

Source sequence(s)

AC170598

Consensus CDS

CCDS22886.1

UniProtKB/Swiss-Prot

Q8R0Z6

Related

ENSMUSP00000035784.7, ENSMUST00000043726.8

Conserved Domains (2) summary

cd00087
Location:242 → 453

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam04871
Location:66 → 157

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

20785104..20791116 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242599.4 → XP_011240901.1 angiopoietin-related protein 6 isoform X1

Conserved Domains (3) summary

PRK09039
Location:57 → 154

PRK09039; peptidoglycan -binding protein

cd00087
Location:259 → 470

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam04709
Location:116 → 197

AMH_N; Anti-Mullerian hormone, N terminal region
XM_011242600.2 → XP_011240902.1 angiopoietin-related protein 6 isoform X2

Conserved Domains (1) summary

cd00087
Location:81 → 292

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...