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    Itgb3bp integrin beta 3 binding protein (beta3-endonexin) [ Mus musculus (house mouse) ]

    Gene ID: 67733, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Itgb3bpprovided by MGI
    Official Full Name
    integrin beta 3 binding protein (beta3-endonexin)provided by MGI
    Primary source
    MGI:MGI:1914983
    See related
    Ensembl:ENSMUSG00000028549 AllianceGenome:MGI:1914983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CENP-R; 4930471O16Rik
    Summary
    Predicted to be involved in CENP-A containing chromatin assembly and regulation of transcription, DNA-templated. Predicted to act upstream of or within apoptotic process and cell division. Predicted to be located in kinetochore and nucleus. Predicted to be active in nucleoplasm. Is expressed in brain; ovary; seminiferous tubule; spermatocyte; and spermatogonium. Orthologous to human ITGB3BP (integrin subunit beta 3 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 2.2), CNS E11.5 (RPKM 1.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C6; 4 45.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99655643..99717403, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99767406..99829215, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10873 Neighboring gene forkhead box D3 Neighboring gene STARR-positive B cell enhancer ABC_E6192 Neighboring gene STARR-seq mESC enhancer starr_10875 Neighboring gene ALG6 alpha-1,3-glucosyltransferase Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:99495752-99496005 Neighboring gene EF-hand calcium binding domain 7 Neighboring gene STARR-positive B cell enhancer ABC_E6193 Neighboring gene predicted gene, 26425 Neighboring gene phosphoglucomutase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model. Okumura K, et al. Cancer Sci, 2017 Nov. PMID 28795467, Free PMC Article
    2. Reduced beta3-endonexin levels are associated with enhanced urokinase-type plasminogen activator receptor expression in ApoE-/- mice. Besta F, et al. Thromb Res, 2004. PMID 15381392
    3. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590
    4. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein R
    Names
    nuclear receptor-interacting factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362974.1 → NP_001349903.1  centromere protein R isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK165072
      Conserved Domains (1) summary
      pfam06729
      Location:8 → 85
      CENP-R; Kinetochore component, CENP-R

    2. NM_001362975.1 → NP_001349904.1  centromere protein R isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX005053, BX324127
      Conserved Domains (1) summary
      pfam06729
      Location:8 → 84
      CENP-R; Kinetochore component, CENP-R

    3. NM_001362976.1 → NP_001349905.1  centromere protein R isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX005053, BX324127
      Related
      ENSMUST00000102786.11
      Conserved Domains (1) summary
      pfam06729
      Location:1 → 77
      CENP-R; Kinetochore component, CENP-R

    4. NM_026348.4 → NP_080624.1  centromere protein R isoform 1

      See identical proteins and their annotated locations for NP_080624.1

      Status: VALIDATED

      Source sequence(s)
      AK045037, AK165072
      Consensus CDS
      CCDS18387.1
      UniProtKB/Swiss-Prot
      Q3TLR0, Q3TNR4, Q9CQ82
      Related
      ENSMUSP00000117153.2, ENSMUST00000146258.2
      Conserved Domains (1) summary
      pfam06729
      Location:25 → 161
      CENP-R; Kinetochore component, CENP-R

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      99655643..99717403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240600.4 → XP_011238902.1  centromere protein R isoform X1

      Conserved Domains (1) summary
      pfam06729
      Location:27 → 162
      CENP-R; Kinetochore component, CENP-R
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ82.1 GenPept UniProtKB/Swiss-Prot:Q9CQ82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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