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    Carmil3 capping protein regulator and myosin 1 linker 3 [ Mus musculus (house mouse) ]

    Gene ID: 268747, updated on 11-Apr-2024

    Summary

    Official Symbol
    Carmil3provided by MGI
    Official Full Name
    capping protein regulator and myosin 1 linker 3provided by MGI
    Primary source
    MGI:MGI:2448573
    See related
    Ensembl:ENSMUSG00000022211 AllianceGenome:MGI:2448573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrrc16b; mFLJ00240
    Summary
    Predicted to be located in plasma membrane. Is expressed in central nervous system; dorsal root ganglion; extraembryonic component; and olfactory epithelium. Orthologous to human CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 51.3), CNS E14 (RPKM 47.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    14 C3; 14 28.19 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55728108..55745729)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55490651..55508272)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41158 Neighboring gene dehydrogenase/reductase 4 Neighboring gene copine VI Neighboring gene neural retina leucine zipper gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    capping protein, Arp2/3 and myosin-I linker protein 3
    Names
    capping protein regulator and myosin 1 linker protein 3
    leucine-rich repeat-containing protein 16B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024645.2NP_001019816.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001019816.1

      Status: VALIDATED

      Source sequence(s)
      AK148355, AK158466, BC060252, BC082805
      Consensus CDS
      CCDS36930.1
      UniProtKB/Swiss-Prot
      Q3UFQ8, Q6KAP3
      Related
      ENSMUSP00000075587.6, ENSMUST00000076236.7
      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781061
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_001374103.1NP_001361032.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159002
      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. NM_001374104.1NP_001361033.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159002
      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781061
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. NM_001374105.1NP_001361034.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159002
      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781061
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RNA

    1. NR_155103.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159002
      Related
      ENSMUST00000228877.2
    2. NR_155104.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK148355, AK158466, BC082805
      Related
      ENSMUST00000227312.2
    3. NR_164326.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159002
      Related
      ENSMUST00000226757.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55728108..55745729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247836.2XP_030103696.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

      Conserved Domains (1) summary
      pfam16000
      Location:198483
      CARMIL_C; CARMIL C-terminus
    2. XM_030247833.2XP_030103693.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X13

      Conserved Domains (4) summary
      sd00033
      Location:6997
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:3967
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:572856
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:101394
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_006519058.4XP_006519121.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16

      Conserved Domains (3) summary
      sd00033
      Location:1445
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:399683
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:37249
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_006519056.4XP_006519119.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

      See identical proteins and their annotated locations for XP_006519119.1

      Conserved Domains (4) summary
      sd00033
      Location:128156
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:98126
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:631915
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:160453
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_006519047.5XP_006519110.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    6. XM_006519049.5XP_006519112.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    7. XM_006519050.5XP_006519113.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    8. XM_017316027.3XP_017171516.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    9. XM_036158607.1XP_036014500.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781063
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    10. XM_006519053.5XP_006519116.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    11. XM_030247832.2XP_030103692.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    12. XM_006519048.5XP_006519111.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781061
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    13. XM_030247830.2XP_030103690.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781061
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    14. XM_036158608.1XP_036014501.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

      Conserved Domains (5) summary
      sd00033
      Location:275303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7781062
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:307600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    15. XM_030247835.2XP_030103695.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16

      Conserved Domains (3) summary
      sd00033
      Location:1445
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:399683
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:37249
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    16. XM_036158610.1XP_036014503.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

      Conserved Domains (1) summary
      pfam16000
      Location:198483
      CARMIL_C; CARMIL C-terminus
    17. XM_030247834.2XP_030103694.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X14

      Conserved Domains (3) summary
      sd00033
      Location:5381
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:495779
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:24272
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    18. XM_036158609.1XP_036014502.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X15

      Conserved Domains (3) summary
      sd00033
      Location:5381
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:495779
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:24272
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    19. XM_006519054.5XP_006519117.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

      Conserved Domains (4) summary
      sd00033
      Location:261289
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7641048
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:30118
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:293586
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    20. XM_006519055.5XP_006519118.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

      See identical proteins and their annotated locations for XP_006519118.1

      Conserved Domains (4) summary
      sd00033
      Location:128156
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:98126
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:631915
      CARMIL_C; CARMIL C-terminus
      cl39015
      Location:160453
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    21. XM_006519060.4XP_006519123.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X18

      Related
      ENSMUST00000226388.2
      Conserved Domains (1) summary
      pfam16000
      Location:110394
      CARMIL_C; CARMIL C-terminus
    22. XM_006519061.4XP_006519124.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X19

      Conserved Domains (1) summary
      pfam16000
      Location:91375
      CARMIL_C; CARMIL C-terminus

    RNA

    1. XR_004938405.1 RNA Sequence

    2. XR_383182.5 RNA Sequence

    3. XR_004938403.1 RNA Sequence

    4. XR_004938406.1 RNA Sequence

    5. XR_004938404.1 RNA Sequence

    6. XR_383183.5 RNA Sequence