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    Rprd2 regulation of nuclear pre-mRNA domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 75137, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rprd2provided by MGI
    Official Full Name
    regulation of nuclear pre-mRNA domain containing 2provided by MGI
    Primary source
    MGI:MGI:1922387
    See related
    Ensembl:ENSMUSG00000028106 AllianceGenome:MGI:1922387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0460; 2810036A19Rik; 4930535B03Rik; 6720469I21Rik
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be part of RNA polymerase II, holoenzyme. Is expressed in several structures, including blastocyst; early embryo; and extraembryonic component. Orthologous to human RPRD2 (regulation of nuclear pre-mRNA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 5.3), limb E14.5 (RPKM 5.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rprd2 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95667183..95727034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95759871..95819744, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene STARR-positive B cell enhancer ABC_E2087 Neighboring gene predicted gene, 26361 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene STARR-seq mESC enhancer starr_08396 Neighboring gene predicted gene, 29948 Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene mitochondrial ribosomal protein S21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
    2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulation of nuclear pre-mRNA domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081293.2 → NP_001074762.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001074762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC093317, BC067054
      Consensus CDS
      CCDS38549.1
      UniProtKB/Swiss-Prot
      Q3U3L8, Q6NXI6, Q6ZQA7
      UniProtKB/TrEMBL
      A0A0G2JFW6
      Related
      ENSMUSP00000088297.4, ENSMUST00000090791.8
      Conserved Domains (1) summary
      smart00582
      Location:27 → 145
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA

    2. NM_001368178.2 → NP_001355107.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093317, FQ790371
      UniProtKB/TrEMBL
      A0A0G2JFW6

    3. NM_001368179.1 → NP_001355108.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC093317, FQ790371
      UniProtKB/TrEMBL
      A0A0G2JFW6
      Related
      ENSMUSP00000143333.2, ENSMUST00000200164.5

    4. NM_001368180.1 → NP_001355109.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093317

    5. NM_001368181.1 → NP_001355110.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093317

    6. NM_028328.2 → NP_082604.2  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093317
      Consensus CDS
      CCDS89669.1
      UniProtKB/TrEMBL
      A0A0G2JFN1
      Related
      ENSMUSP00000143240.2, ENSMUST00000197449.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95667183..95727034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252863.2 → XP_030108723.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JFW6
      Conserved Domains (3) summary
      PRK03918
      Location:142 → 318
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam05109
      Location:319 → 645
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd17001
      Location:27 → 146
      CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2

    2. XM_011240267.4 → XP_011238569.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      pfam05109
      Location:293 → 619
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd17001
      Location:27 → 145
      CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029180.1: Suppressed sequence

      Description
      NM_029180.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXI6.1 GenPept UniProtKB/Swiss-Prot:Q6NXI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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