Tfcp2 transcription factor CP2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfcp2provided by MGI
Official Full Name: transcription factor CP2provided by MGI
Primary source: MGI:MGI:98509
See related: Ensembl:ENSMUSG00000009733 AllianceGenome:MGI:98509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CP2; LSF; CP-2; LBP1; UBP-1; LBP-1c; LBP-1d; Tcfcp2; D230015P20Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 6.2), CNS E11.5 (RPKM 6.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.33 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100395083..100449896, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100497781..100552014, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.
Title: TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.
Mbd2-CP2c functional loop drives adult-type globin gene expression and erythroid differentiation of erythroid cells.
Title: Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis.
The transcription factor CP2 upregulated miR-144 expression, which partially contributed to the suppression of COX-2 in mGCs.
Title: MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells.
that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
Title: Reciprocal localization of transcription factors YY1 and CP2c in spermatogonial stem cells and their putative roles during spermatogenesis.
Small molecule inhibitors of Late SV40 Factor abrogate hepatocellular carcinoma by inducing mitotic arrest and apoptosis.
Title: Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma
Title: Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.
present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin promoter upon EMT induction by Snail1
Title: TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression.
the binding of Pin1 at the Thr-329-Pro-330 motif in LSF permits isomerization by Pin1 of the peptide bonds at the nearby phosphorylated SP motifs (Ser-291 and Ser-309) to the trans configuration, thereby facilitating their dephosphorylation.
Title: Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.
CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin expression via up-regulating its transcription.
Title: Control of transferrin expression by β-amyloid through the CP2 transcription factor.
Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
Title: Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

fb05b02.x1 (e-PCR)
- UniSTS:202690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: alpha-globin transcription factor CP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289603.1 → NP_001276532.1 alpha-globin transcription factor CP2 isoform 2

See identical proteins and their annotated locations for NP_001276532.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC123724, AC139571

Consensus CDS

CCDS88846.1

UniProtKB/TrEMBL

A0A2R8VKI7

Related

ENSMUSP00000009877.8, ENSMUST00000009877.8

Conserved Domains (2) summary

pfam04516
Location:52 → 257

CP2; CP2 transcription factor

cl15755
Location:329 → 393

SAM_superfamily; SAM (Sterile alpha motif )
NM_001355497.1 → NP_001342426.1 alpha-globin transcription factor CP2 isoform 3

Status: VALIDATED

Source sequence(s)

AC123724, AC139571

UniProtKB/TrEMBL

A0A2R8VKI7

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 257

CP2; CP2 transcription factor
NM_033476.3 → NP_258437.1 alpha-globin transcription factor CP2 isoform 1

See identical proteins and their annotated locations for NP_258437.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC139571, AK146503

Consensus CDS

CCDS27840.1

UniProtKB/Swiss-Prot

Q3UGJ4, Q8VC13, Q9ERA0

UniProtKB/TrEMBL

A0A2R8VKI7

Related

ENSMUSP00000155683.2, ENSMUST00000229696.2

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 259

CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

100395083..100449896 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316538.3 → XP_017172027.1 alpha-globin transcription factor CP2 isoform X2

UniProtKB/TrEMBL

A0A2R8VKI7

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 257

CP2; CP2 transcription factor
XM_017316537.2 → XP_017172026.1 alpha-globin transcription factor CP2 isoform X1

UniProtKB/TrEMBL

A0A2R8VKI7

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 257

CP2; CP2 transcription factor
XM_017316539.1 → XP_017172028.1 alpha-globin transcription factor CP2 isoform X1

UniProtKB/TrEMBL

A0A2R8VKI7

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 257

CP2; CP2 transcription factor
XM_036159310.1 → XP_036015203.1 alpha-globin transcription factor CP2 isoform X6

Conserved Domains (2) summary

cd09589
Location:132 → 198

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:6 → 62

CP2; CP2 transcription factor
XM_030248456.2 → XP_030104316.1 alpha-globin transcription factor CP2 isoform X6

Conserved Domains (2) summary

cd09589
Location:132 → 198

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:6 → 62

CP2; CP2 transcription factor
XM_030248455.2 → XP_030104315.1 alpha-globin transcription factor CP2 isoform X6

Conserved Domains (2) summary

cd09589
Location:132 → 198

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:6 → 62

CP2; CP2 transcription factor
XM_036159311.1 → XP_036015204.1 alpha-globin transcription factor CP2 isoform X6

Conserved Domains (2) summary

cd09589
Location:132 → 198

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:6 → 62

CP2; CP2 transcription factor
XM_017316541.2 → XP_017172030.1 alpha-globin transcription factor CP2 isoform X5

Conserved Domains (2) summary

cd09589
Location:174 → 240

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:15 → 102

CP2; CP2 transcription factor
XM_006520738.3 → XP_006520801.2 alpha-globin transcription factor CP2 isoform X3

UniProtKB/TrEMBL

A0A2R8VKI7

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 257

CP2; CP2 transcription factor
XM_036159309.1 → XP_036015202.1 alpha-globin transcription factor CP2 isoform X4

UniProtKB/Swiss-Prot

Q3UGJ4, Q8VC13, Q9ERA0

UniProtKB/TrEMBL

A0A2R8VKI7

Related

ENSMUSP00000155581.2, ENSMUST00000229581.2

Conserved Domains (2) summary

cd09589
Location:329 → 395

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:52 → 259

CP2; CP2 transcription factor
XM_036159312.1 → XP_036015205.1 alpha-globin transcription factor CP2 isoform X8

UniProtKB/TrEMBL

Q3URS4

Conserved Domains (2) summary

cd09589
Location:132 → 198

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:6 → 62

CP2; CP2 transcription factor
XM_030248457.2 → XP_030104317.1 alpha-globin transcription factor CP2 isoform X7

UniProtKB/TrEMBL

Q3URS4

Conserved Domains (2) summary

cd09589
Location:132 → 198

SAM_TFCP2; SAM domain of TFCP2 transcription factors

pfam04516
Location:6 → 60

CP2; CP2 transcription factor