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    Ercc6l2 excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 76251, updated on 22-Aug-2021

    Summary

    Official Symbol
    Ercc6l2provided by MGI
    Official Full Name
    excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2provided by MGI
    Primary source
    MGI:MGI:1923501
    See related
    Ensembl:ENSMUSG00000021470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sr278; Rad26l; 0610007P08Rik; 1700019D06Rik; 9330134C04Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 2.2), bladder adult (RPKM 2.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ercc6l2 in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63958793..64048116)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (63810979..63900302)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (63916628..64001610)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm702 Neighboring gene predicted gene, 30709 Neighboring gene RIKEN cDNA 1700024I08 gene Neighboring gene predicted gene, 46423 Neighboring gene predicted gene, 30950

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Homology

    Clone Names

    • MGC100170

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA excision repair protein ERCC-6-like 2
    Names
    DNA repair and recombination protein RAD26-like
    putative repair and recombination helicase RAD26L
    stretch responsive protein 278

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013608.3NP_001013626.2  DNA excision repair protein ERCC-6-like 2 isoform 1

      See identical proteins and their annotated locations for NP_001013626.2

      Status: VALIDATED

      Source sequence(s)
      AC154248
      Consensus CDS
      CCDS26593.2
      UniProtKB/Swiss-Prot
      Q9JIM3
      Related
      ENSMUSP00000158755.2, ENSMUST00000238465.2
      Conserved Domains (4) summary
      cd00046
      Location:141300
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:125460
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:505619
      Helicase_C; Helicase conserved C-terminal domain
      pfam14773
      Location:11081131
      VIGSSK; Helicase-associated putative binding domain, C-terminal
    2. NM_001361124.1NP_001348053.1  DNA excision repair protein ERCC-6-like 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154248, AK082850
      Related
      ENSMUSP00000021926.7, ENSMUST00000021926.13
      Conserved Domains (1) summary
      COG0553
      Location:81466
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    3. NM_023507.4NP_075996.2  DNA excision repair protein ERCC-6-like 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154248
      Consensus CDS
      CCDS36701.1
      UniProtKB/Swiss-Prot
      Q9JIM3
      Related
      ENSMUSP00000069488.6, ENSMUST00000067821.13
      Conserved Domains (3) summary
      cd00046
      Location:141300
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:125460
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:505619
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      63958793..64048116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517451.4XP_006517514.1  DNA excision repair protein ERCC-6-like 2 isoform X4

      Conserved Domains (4) summary
      cd04508
      Location:2070
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      COG0553
      Location:72649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:11011131
      VIGSSK; Helicase-associated putative binding domain, C-terminal
    2. XM_017315632.2XP_017171121.1  DNA excision repair protein ERCC-6-like 2 isoform X1

      Conserved Domains (3) summary
      COG0553
      Location:72649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:10741104
      VIGSSK; Helicase-associated putative binding domain, C-terminal
    3. XM_017315633.2XP_017171122.1  DNA excision repair protein ERCC-6-like 2 isoform X2

      Conserved Domains (3) summary
      COG0553
      Location:72609
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122329
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:10611091
      VIGSSK; Helicase-associated putative binding domain, C-terminal
    4. XM_030247457.1XP_030103317.1  DNA excision repair protein ERCC-6-like 2 isoform X3

      Conserved Domains (3) summary
      COG0553
      Location:2364
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18793
      Location:219345
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam14773
      Location:816846
      VIGSSK; Helicase-associated putative binding domain, C-terminal
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