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    Ces5a carboxylesterase 5A [ Mus musculus (house mouse) ]

    Gene ID: 67935, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ces5aprovided by MGI
    Official Full Name
    carboxylesterase 5Aprovided by MGI
    Primary source
    MGI:MGI:1915185
    See related
    Ensembl:ENSMUSG00000058019 AllianceGenome:MGI:1915185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces7; Gm503; cauxin; 1700081L16Rik; 1700122C07Rik
    Summary
    Predicted to enable methyl indole-3-acetate esterase activity. Predicted to be located in extracellular region. Orthologous to human CES5A (carboxylesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 296.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C5; 8 45.67 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94225691..94262507, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93499063..93535879, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22334 Neighboring gene STARR-seq mESC enhancer starr_22335 Neighboring gene carboxylesterase 1H Neighboring gene STARR-seq mESC enhancer starr_22336 Neighboring gene predicted gene, 30132 Neighboring gene STARR-seq mESC enhancer starr_22337 Neighboring gene STARR-seq mESC enhancer starr_22338 Neighboring gene STARR-seq mESC enhancer starr_22339 Neighboring gene predicted gene, 26843 Neighboring gene STARR-seq mESC enhancer starr_22341 Neighboring gene predicted gene, 30606 Neighboring gene STARR-seq mESC enhancer starr_22342 Neighboring gene predicted gene, 39224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase. Miyazaki M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2006 Nov-Dec. PMID 17045831
    2. Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. Robertson MJ, et al. BMC Biol, 2020 Aug 19. PMID 32814578, Free PMC Article
    3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 5A
    Names
    carboxylesterase 7
    carboxylesterase-like urinary excreted protein homolog
    NP_001003951.1
    NP_001368779.1
    XP_006531384.1
    XP_006531385.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003951.3 → NP_001003951.1  carboxylesterase 5A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001003951.1

      Status: VALIDATED

      Source sequence(s)
      AC124591, AC162945
      Consensus CDS
      CCDS85584.1
      UniProtKB/Swiss-Prot
      Q6AW46
      Related
      ENSMUSP00000148481.2, ENSMUST00000212009.2
      Conserved Domains (2) summary
      COG0657
      Location:126 → 229
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:31 → 539
      COesterase; Carboxylesterase family

    2. NM_001381850.1 → NP_001368779.1  carboxylesterase 5A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124591, AC162945
      Conserved Domains (1) summary
      pfam00135
      Location:33 → 543
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94225691..94262507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531321.3 → XP_006531384.1  carboxylesterase 5A isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:35 → 452
      Abhydrolase; alpha/beta hydrolases

    2. XM_006531322.5 → XP_006531385.1  carboxylesterase 5A isoform X2

      Conserved Domains (1) summary
      pfam00135
      Location:1 → 423
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AW46.1 GenPept UniProtKB/Swiss-Prot:Q6AW46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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