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    Prpf6 pre-mRNA splicing factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 68879, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Prpf6provided by MGI
    Official Full Name
    pre-mRNA splicing factor 6provided by MGI
    Primary source
    MGI:MGI:1922946
    See related
    Ensembl:ENSMUSG00000002455 AllianceGenome:MGI:1922946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ANT-1; U5-102K; 1190003A07Rik; 2610031L17Rik
    Summary
    Predicted to enable several functions, including androgen receptor binding activity; identical protein binding activity; and transcription coactivator activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within RNA localization and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.6), placenta adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H4; 2 103.67 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181243112..181297454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181601319..181655661)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 512B Neighboring gene microRNA 7006 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181335875-181336176 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_06756 Neighboring gene predicted gene, 29797 Neighboring gene predicted gene, 25879

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor. Fan S, et al. Biochem Biophys Res Commun, 2006 Mar 3. PMID 16414017
    2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11655, MGC36967, MGC38351

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-processing factor 6
    Names
    PRP6 homolog
    PRP6 pre-mRNA splicing factor 6 homolog
    U5 snRNP-associated 102 kDa protein
    U5-102 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133701.2 → NP_598462.1  pre-mRNA-processing factor 6

      See identical proteins and their annotated locations for NP_598462.1

      Status: VALIDATED

      Source sequence(s)
      AK081998, BY735790, CJ228927
      Consensus CDS
      CCDS38381.1
      UniProtKB/Swiss-Prot
      Q3ULJ7, Q542P0, Q8CIK9, Q8R3M8, Q91YR7, Q99JN1, Q9CSZ0
      Related
      ENSMUSP00000002529.7, ENSMUST00000002529.7
      Conserved Domains (6) summary
      smart00386
      Location:444 → 476
      HAT; HAT (Half-A-TPR) repeats
      sd00006
      Location:708 → 738
      TPR; TPR repeat [structural motif]
      pfam06424
      Location:13 → 169
      PRP1_N; PRP1 splicing factor, N-terminal
      pfam13414
      Location:709 → 774
      TPR_11; TPR repeat
      pfam13428
      Location:404 → 443
      TPR_14; Tetratricopeptide repeat
      pfam14559
      Location:621 → 673
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181243112..181297454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YR7.1 GenPept UniProtKB/Swiss-Prot:Q91YR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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