Tnpo1 transportin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnpo1provided by MGI
Official Full Name: transportin 1provided by MGI
Primary source: MGI:MGI:2681523
See related: Ensembl:ENSMUSG00000009470 AllianceGenome:MGI:2681523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MIP; TRN; IPO2; MIP1; Kpnb2; D13Ertd688e
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 23.2), whole brain E14.5 (RPKM 19.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 52.24 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (98975527..99062851, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (98839019..98926384, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-immunoprecipitation and affinity-binding studies revealed that Rab23 exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 for its ciliary transport
Title: A role for Rab23 in the trafficking of Kif17 to the primary cilium.
Association with Tnpo1 is necessary for Oxtr nuclear localization. This is required for Oxt-induced osteoblast differentiation. osteoblast differentiation.
Title: Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor.
DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
Title: Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein.
Title: Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.
Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
Title: Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237090 (e-PCR)
- UniSTS:237090

AI461913 (e-PCR)
- UniSTS:208975

AU021749 (e-PCR)
- UniSTS:208977

AU015704 (e-PCR)
- UniSTS:167122

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transportin-1

Names: importin beta-2; karyopherin (importin) beta 2; karyopherin beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048267.2 → NP_001041732.1 transportin-1 isoform 2

See identical proteins and their annotated locations for NP_001041732.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC129085, AC154849

Consensus CDS

CCDS36760.1

UniProtKB/TrEMBL

Q3TKD0

Related

ENSMUSP00000105026.3, ENSMUST00000109399.9

Conserved Domains (2) summary

COG5215
Location:24 → 759

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:95 → 116

HEAT; HEAT repeat [structural motif]
NM_001426412.1 → NP_001413341.1 transportin-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC129085, AC154849
NM_001426413.1 → NP_001413342.1 transportin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC129085, AC154849
NM_001426414.1 → NP_001413343.1 transportin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC129085, AC154849
NM_001426415.1 → NP_001413344.1 transportin-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC129085, AC154849
NM_178716.4 → NP_848831.2 transportin-1 isoform 1

See identical proteins and their annotated locations for NP_848831.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC129085, AC154849

Consensus CDS

CCDS26717.2

UniProtKB/Swiss-Prot

Q8BFY9, Q8C0S3, Q8K2E7

UniProtKB/TrEMBL

Q3TKD0

Related

ENSMUSP00000105028.2, ENSMUST00000109401.8

Conserved Domains (2) summary

COG5215
Location:32 → 767

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:103 → 124

HEAT; HEAT repeat [structural motif]