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    Vps36 vacuolar protein sorting 36 [ Mus musculus (house mouse) ]

    Gene ID: 70160, updated on 16-Oct-2021

    Summary

    Official Symbol
    Vps36provided by MGI
    Official Full Name
    vacuolar protein sorting 36provided by MGI
    Primary source
    MGI:MGI:1917410
    See related
    Ensembl:ENSMUSG00000031479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eap45; 1700010A24Rik; 2210415M20Rik; 2810408E15Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.8), bladder adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Vps36 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22682849..22710969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22192833..22220953)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23303332..23329069)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 2 Neighboring gene predicted gene, 29878 Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene thrombospondin, type I, domain 1 Neighboring gene transmembrane phosphatase with tensin homology Neighboring gene predicted gene, 46035

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ESCRT II complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vacuolar protein-sorting-associated protein 36
    Names
    ESCRT-II complex subunit VPS36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368379.1NP_001355308.1  vacuolar protein-sorting-associated protein 36 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117665
    2. NM_027338.2NP_081614.1  vacuolar protein-sorting-associated protein 36 isoform 1

      See identical proteins and their annotated locations for NP_081614.1

      Status: VALIDATED

      Source sequence(s)
      AC117665
      Consensus CDS
      CCDS22171.1
      UniProtKB/Swiss-Prot
      Q91XD6
      UniProtKB/TrEMBL
      Q3TSR1
      Related
      ENSMUSP00000033866.9, ENSMUST00000033866.9
      Conserved Domains (2) summary
      cd13226
      Location:1128
      PH-GRAM-like_Eap45; Pleckstrin homology-like domain or GLUE (GRAM-like ubiquitin-binding in Eap45) domain of Eap45
      pfam04157
      Location:154369
      EAP30; EAP30/Vps36 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22682849..22710969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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