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    Magix MAGI family member, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 54634, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Magixprovided by MGI
    Official Full Name
    MAGI family member, X-linkedprovided by MGI
    Primary source
    MGI:MGI:1859644
    See related
    Ensembl:ENSMUSG00000031147 AllianceGenome:MGI:1859644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdzx; Sfc18
    Summary
    Orthologous to human MAGIX (MAGI family member, X-linked). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 8.4), liver adult (RPKM 6.5) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.1; X 3.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7539405..7547490, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7673166..7681251, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptophysin Neighboring gene predicted gene 14703 Neighboring gene prickle planar cell polarity protein 3 Neighboring gene proteolipid protein 2 Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1 Neighboring gene G patch domain and KOW motifs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
    2. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117659

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    PDZ domain-containing protein MAGIX
    Names
    PDZ domain containing X chromosome

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018832.2 → NP_061302.2  PDZ domain-containing protein MAGIX

      See identical proteins and their annotated locations for NP_061302.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AK158091, BC099459
      Consensus CDS
      CCDS29968.1
      UniProtKB/Swiss-Prot
      Q4KL35, Q9JIG3
      UniProtKB/TrEMBL
      Q3TZ57
      Related
      ENSMUSP00000111359.4, ENSMUST00000115695.4
      Conserved Domains (1) summary
      smart00228
      Location:126 → 211
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    RNA

    1. NR_037581.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon at its 5' end which results in the loss of a translation initiation site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to inhibit the translation of the longest in-frame ORF, compared to variant 1, and the latter ORF is significantly truncated.
      Source sequence(s)
      AK077898, AK158091
      Related
      ENSMUST00000130287.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7539405..7547490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KL35.1 GenPept UniProtKB/Swiss-Prot:Q4KL35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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