Rab37 RAB37, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab37provided by MGI
Official Full Name: RAB37, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1929945
See related: Ensembl:ENSMUSG00000020732 AllianceGenome:MGI:1929945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B230331O03Rik; B230354I04Rik
Summary: Predicted to enable GTPase activity. Predicted to act upstream of or within protein transport. Located in secretory granule. Is expressed in brain and retina. Orthologous to human RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 5.8), frontal lobe adult (RPKM 3.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.59 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114982257..115053066)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115091331..115162773)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.
Title: Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.
Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90alpha and TIMP1.
Title: Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1.
Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
Title: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
Title: Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.
Title: Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
Rab37 interacts with Munc13-1 to control TNF-alpha secretion from activated macrophages
Title: Release of TNF-α from macrophages is mediated by small GTPase Rab37.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Dcr29 (e-PCR), detects polymorphism
- UniSTS:507473

D11Mit214 (e-PCR), detects polymorphism
- UniSTS:116393

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-37

Names: GTPase Rab37; RAB37, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163753.1 → NP_001157225.1 ras-related protein Rab-37 isoform 2

See identical proteins and their annotated locations for NP_001157225.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs at the 5' end, and is missing two in-frame coding exons compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AK046260, BB084455

Consensus CDS

CCDS48979.1

UniProtKB/TrEMBL

Q8BQX0

Related

ENSMUSP00000065016.5, ENSMUST00000067754.11

Conserved Domains (1) summary

cd04112
Location:23 → 213

Rab26; Rab GTPase family 26 (Rab26)
NM_021411.4 → NP_067386.3 ras-related protein Rab-37 isoform 1

See identical proteins and their annotated locations for NP_067386.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK040216, AK050483, BB084455, BY131048

Consensus CDS

CCDS25620.1

UniProtKB/Swiss-Prot

Q8C7E1, Q9JKM7

UniProtKB/TrEMBL

Q544E8

Related

ENSMUSP00000021076.6, ENSMUST00000021076.6

Conserved Domains (1) summary

cd04112
Location:31 → 220

Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

114982257..115053066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156872.1 → XP_036012765.1 ras-related protein Rab-37 isoform X1

Conserved Domains (1) summary

cl38936
Location:31 → 144

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases