Birc2 baculoviral IAP repeat-containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Birc2provided by MGI
Official Full Name: baculoviral IAP repeat-containing 2provided by MGI
Primary source: MGI:MGI:1197009
See related: Ensembl:ENSMUSG00000057367 AllianceGenome:MGI:1197009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc3; HIAP1; HIAP2; MIAP1; MIAP2; RNF48; cIAP1; cIAP2; C-IAP1; mcIAP1; C330006D17Rik
Summary: Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in necroptotic process. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in brain ventricular layer; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.0), CNS E14 (RPKM 8.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (7818227..7837123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (7818226..7837131, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha.
Title: IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Results identify IGF2BP1 as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.
Title: IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.
Identify xIAP and cIAP1 as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
Title: Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression.
NFATc1 mRNA expression is negatively regulated by inhibitor of apoptosis protein 2 during osteoclastogenesis.
Title: cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression.
cIAP1 expression protects macrophages from Rip1-dependent necroptotic cell death and facilitates pathogen control.
Title: cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.
cIAP1 plays a critical role in beta-cell survival under endoplasmic reticulum stress: by promoting ubiquitination and degradation of C/EBP homologous protein (CHOP)
Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP).
Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3) impaired caspase-1 activation after spontaneous or agonist-induced inflammasome assembly.
Title: Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.
fundamental role for cIAP1/cIAP2 in regulating B-cell survival and responsiveness
Title: Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
These findings identify critical role of cIAP1, cIAP2 and Yap1 co-expression in mammary carcinogenesis
Title: Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.
TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2.
Title: TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236050

AW146227 (e-PCR)
- UniSTS:179861

L49433 (e-PCR)
- UniSTS:124913

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FBXO family protein binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	IGI Inferred from Genetic Interaction more info	PubMed
involved_in necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein monoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein polyubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CD40 receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in XY body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 2

Names: IAP-2; RING-type E3 ubiquitin transferase BIRC2; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; cellular inhibitor of apoptosis 1; inhibitor of apoptosis protein 2; mIAP-2

NP_001278432.1

EC 2.3.2.27

NP_031491.2

EC 2.3.2.27

XP_017168599.1

EC 2.3.2.27

XP_017168600.1

EC 2.3.2.27

XP_030099889.1

EC 2.3.2.27

XP_036010465.1

EC 2.3.2.27

XP_036010466.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291503.1 → NP_001278432.1 baculoviral IAP repeat-containing protein 2

See identical proteins and their annotated locations for NP_001278432.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.

Source sequence(s)

AA144490, BC145985, CT030639

Consensus CDS

CCDS22811.1

UniProtKB/Swiss-Prot

A6H6S7, O08864, Q62210

Conserved Domains (5) summary

smart00238
Location:176 → 245

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd08329
Location:447 → 538

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:385 → 431

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:559 → 612

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
NM_007465.3 → NP_031491.2 baculoviral IAP repeat-containing protein 2

See identical proteins and their annotated locations for NP_031491.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AA144490, BC145985, CT030639

Consensus CDS

CCDS22811.1

UniProtKB/Swiss-Prot

A6H6S7, O08864, Q62210

Related

ENSMUSP00000140049.2, ENSMUST00000190341.7

Conserved Domains (5) summary

smart00238
Location:176 → 245

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd08329
Location:447 → 538

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:385 → 431

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:559 → 612

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

7818227..7837123 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313111.2 → XP_017168600.1 baculoviral IAP repeat-containing protein 2 isoform X2

Conserved Domains (5) summary

smart00238
Location:45 → 114

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:385 → 431

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:474 → 527

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:180 → 244

BIR; Inhibitor of Apoptosis domain
XM_030244029.2 → XP_030099889.1 baculoviral IAP repeat-containing protein 2 isoform X2

Conserved Domains (5) summary

smart00238
Location:45 → 114

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:385 → 431

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:474 → 527

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:180 → 244

BIR; Inhibitor of Apoptosis domain
XM_036154572.1 → XP_036010465.1 baculoviral IAP repeat-containing protein 2 isoform X2

Conserved Domains (5) summary

smart00238
Location:45 → 114

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14394
Location:385 → 431

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:474 → 527

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

pfam00653
Location:180 → 244

BIR; Inhibitor of Apoptosis domain
XM_017313110.2 → XP_017168599.1 baculoviral IAP repeat-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

A6H6S7, O08864, Q62210

Related

ENSMUSP00000091422.5, ENSMUST00000074246.7

Conserved Domains (5) summary

smart00238
Location:176 → 245

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd08329
Location:447 → 538

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:385 → 431

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:559 → 612

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_036154573.1 → XP_036010466.1 baculoviral IAP repeat-containing protein 2 isoform X3

Conserved Domains (3) summary

smart00238
Location:45 → 114

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:263 → 329

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

pfam00653
Location:180 → 244

BIR; Inhibitor of Apoptosis domain