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    Nol4l nucleolar protein 4-like [ Mus musculus (house mouse) ]

    Gene ID: 329540, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nol4lprovided by MGI
    Official Full Name
    nucleolar protein 4-likeprovided by MGI
    Primary source
    MGI:MGI:1918765
    See related
    Ensembl:ENSMUSG00000061411 AllianceGenome:MGI:1918765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1636; 4931410H15; 8430427H17Rik
    Summary
    Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including gallbladder; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human NOL4L (nucleolar protein 4 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 47.6), whole brain E14.5 (RPKM 15.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 75.41 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153249381..153371869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153407461..153530239, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2500004C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7869 Neighboring gene STARR-seq mESC enhancer starr_06089 Neighboring gene STARR-positive B cell enhancer ABC_E7870 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene predicted gene 14472 Neighboring gene RIKEN cDNA 4930404H24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153351610-153351793 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153351903-153352104 Neighboring gene STARR-seq mESC enhancer starr_06100 Neighboring gene STARR-seq mESC enhancer starr_06102 Neighboring gene COMM domain containing 7 Neighboring gene DNA methyltransferase 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer. Lin F, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33940382
    2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
      Title: NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001986.3 → NP_001001986.2  nucleolar protein 4-like isoform 1

      See identical proteins and their annotated locations for NP_001001986.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AL844144
      Consensus CDS
      CCDS50757.1
      UniProtKB/TrEMBL
      Q3TZG8, Q52KQ8
      Related
      ENSMUSP00000105407.2, ENSMUST00000109784.2

    2. NM_001134300.3 → NP_001127772.1  nucleolar protein 4-like isoform 2

      See identical proteins and their annotated locations for NP_001127772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AL844144
      Consensus CDS
      CCDS50758.1
      UniProtKB/TrEMBL
      Q3UH85
      Related
      ENSMUSP00000036571.8, ENSMUST00000035346.14

    3. NM_001408233.1 → NP_001395162.1  nucleolar protein 4-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844144
      UniProtKB/TrEMBL
      Q3TZG8

    4. NM_001408234.1 → NP_001395163.1  nucleolar protein 4-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844144
      UniProtKB/TrEMBL
      Q3TZG8

    5. NM_001408235.1 → NP_001395164.1  nucleolar protein 4-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844144

    6. NM_001408236.1 → NP_001395165.1  nucleolar protein 4-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844144

    7. NM_001408237.1 → NP_001395166.1  nucleolar protein 4-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL844144

    8. NM_001408238.1 → NP_001395167.1  nucleolar protein 4-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844144

    9. NM_001408239.1 → NP_001395168.1  nucleolar protein 4-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844144

    10. NM_001408240.1 → NP_001395169.1  nucleolar protein 4-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844144

    11. NM_001408241.1 → NP_001395170.1  nucleolar protein 4-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL844144

    12. NM_001408242.1 → NP_001395171.1  nucleolar protein 4-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL844144

    13. NM_001408243.1 → NP_001395172.1  nucleolar protein 4-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL844144

    14. NM_001408244.1 → NP_001395173.1  nucleolar protein 4-like isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL844144

    15. NM_001408245.1 → NP_001395174.1  nucleolar protein 4-like isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL844144

    RNA

    1. NR_176615.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844144

    2. NR_176616.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844144

    3. NR_176617.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844144
      Related
      ENSMUST00000129385.8

    4. NR_176618.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844144

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153249381..153371869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239636.3 → XP_011237938.1  nucleolar protein 4-like isoform X10

      UniProtKB/TrEMBL
      Q52KQ8

    2. XM_006499781.4 → XP_006499844.1  nucleolar protein 4-like isoform X3

      UniProtKB/Swiss-Prot
      Q6DIB4
      Conserved Domains (1) summary
      pfam17921
      Location:32 → 86
      Integrase_H2C2; Integrase zinc binding domain

    3. XM_006499780.4 → XP_006499843.1  nucleolar protein 4-like isoform X2

      UniProtKB/Swiss-Prot
      Q6DIB4
      Conserved Domains (1) summary
      pfam17921
      Location:51 → 105
      Integrase_H2C2; Integrase zinc binding domain

    4. XM_006499784.5 → XP_006499847.1  nucleolar protein 4-like isoform X5

      See identical proteins and their annotated locations for XP_006499847.1

      UniProtKB/Swiss-Prot
      Q6DIB4

    5. XM_006499783.5 → XP_006499846.1  nucleolar protein 4-like isoform X5

      See identical proteins and their annotated locations for XP_006499846.1

      UniProtKB/Swiss-Prot
      Q6DIB4

    6. XM_036162331.1 → XP_036018224.1  nucleolar protein 4-like isoform X8

      UniProtKB/TrEMBL
      Q3TZG8, Q52KQ8

    7. XM_006499786.4 → XP_006499849.1  nucleolar protein 4-like isoform X8

      See identical proteins and their annotated locations for XP_006499849.1

      UniProtKB/TrEMBL
      Q3TZG8, Q52KQ8

    8. XM_006499788.5 → XP_006499851.1  nucleolar protein 4-like isoform X8

      See identical proteins and their annotated locations for XP_006499851.1

      UniProtKB/TrEMBL
      Q3TZG8, Q52KQ8

    9. XM_011239629.2 → XP_011237931.1  nucleolar protein 4-like isoform X6

      See identical proteins and their annotated locations for XP_011237931.1

      UniProtKB/TrEMBL
      Q52KQ8

    10. XM_011239633.4 → XP_011237935.1  nucleolar protein 4-like isoform X6

      See identical proteins and their annotated locations for XP_011237935.1

      UniProtKB/TrEMBL
      Q52KQ8

    11. XM_036162333.1 → XP_036018226.1  nucleolar protein 4-like isoform X9

      UniProtKB/TrEMBL
      Q52KQ8

    12. XM_011239632.3 → XP_011237934.1  nucleolar protein 4-like isoform X6

      See identical proteins and their annotated locations for XP_011237934.1

      UniProtKB/TrEMBL
      Q52KQ8

    13. XM_011239631.3 → XP_011237933.1  nucleolar protein 4-like isoform X6

      See identical proteins and their annotated locations for XP_011237933.1

      UniProtKB/TrEMBL
      Q52KQ8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DIB4.1 GenPept UniProtKB/Swiss-Prot:Q6DIB4

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