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    Dcun1d5 defective in cullin neddylation 1 domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 76863, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dcun1d5provided by MGI
    Official Full Name
    defective in cullin neddylation 1 domain containing 5provided by MGI
    Primary source
    MGI:MGI:1924113
    See related
    Ensembl:ENSMUSG00000032002 AllianceGenome:MGI:1924113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCNL5; 3110001A18Rik; 4833420K19Rik; D430047L21Rik
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including positive regulation of protein modification by small protein conjugation or removal; protein neddylation; and regulation of cell growth. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; jaw; nervous system; and thymus primordium. Orthologous to human DCUN1D5 (defective in cullin neddylation 1 domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.2), adrenal adult (RPKM 24.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcun1d5 in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7176590..7220880)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7176590..7220880)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23196 Neighboring gene predicted gene, 23097 Neighboring gene STARR-seq mESC enhancer starr_23197 Neighboring gene STARR-seq mESC enhancer starr_23198 Neighboring gene STARR-seq mESC enhancer starr_23199 Neighboring gene STARR-seq mESC enhancer starr_23200 Neighboring gene predicted gene, 53497 Neighboring gene STARR-seq mESC enhancer starr_23204 Neighboring gene STARR-seq mESC enhancer starr_23205 Neighboring gene STARR-seq mESC enhancer starr_23206 Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E6712 Neighboring gene predicted gene, 31639 Neighboring gene matrix metallopeptidase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. Thomas Y, et al. PLoS One, 2018. PMID 29958295, Free PMC Article
    2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling.
      Title: The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 5
    Names
    DCN1, defective in cullin neddylation 1, domain containing 5
    DCUN1 domain-containing protein 5
    defective in cullin neddylation protein 1-like protein 5
    squamous cell carcinoma-related oncogene 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357483.1 → NP_001344412.1  DCN1-like protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC174457, AK012764, AK134862, CO801841
      Consensus CDS
      CCDS90493.1
      UniProtKB/TrEMBL
      A0A1N9M8A6
      Related
      ENSMUSP00000034499.10, ENSMUST00000034499.10
      Conserved Domains (1) summary
      pfam03556
      Location:120 → 185
      Cullin_binding; Cullin binding

    2. NM_001357484.1 → NP_001344413.1  DCN1-like protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and contains an alternate exon in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC155908, AC174457
      Conserved Domains (1) summary
      pfam03556
      Location:51 → 161
      Cullin_binding; Cullin binding

    3. NM_029775.3 → NP_084051.1  DCN1-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_084051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC174457, AK134862, CO801841
      Consensus CDS
      CCDS40529.1
      UniProtKB/Swiss-Prot
      Q5XKI2, Q9CUS4, Q9CXV9
      Related
      ENSMUSP00000150564.2, ENSMUST00000215683.2
      Conserved Domains (1) summary
      pfam03556
      Location:120 → 230
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7176590..7220880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509889.5 → XP_006509952.1  DCN1-like protein 5 isoform X2

      Conserved Domains (1) summary
      pfam03556
      Location:120 → 219
      Cullin_binding; Cullin binding

    2. XM_030244711.1 → XP_030100571.1  DCN1-like protein 5 isoform X1

      Conserved Domains (1) summary
      pfam03556
      Location:199 → 309
      Cullin_binding; Cullin binding

    RNA

    1. XR_004935592.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXV9.1 GenPept UniProtKB/Swiss-Prot:Q9CXV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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