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    Ppp1r14c protein phosphatase 1, regulatory inhibitor subunit 14C [ Mus musculus (house mouse) ]

    Gene ID: 76142, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp1r14cprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory inhibitor subunit 14Cprovided by MGI
    Primary source
    MGI:MGI:1923392
    See related
    Ensembl:ENSMUSG00000040653 AllianceGenome:MGI:1923392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KEPI; 6330514J04Rik
    Summary
    Enables protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in regulation of phosphorylation. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Is expressed in heart. Used to study Coronavirus infectious disease. Orthologous to human PPP1R14C (protein phosphatase 1 regulatory inhibitor subunit 14C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 27.4), CNS E18 (RPKM 13.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A1; 10 2.06 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (3315974..3414975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (3365974..3464978)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29826 Neighboring gene predicted gene, 40590 Neighboring gene predicted gene, 26752 Neighboring gene predicted gene, 29987 Neighboring gene iodotyrosine deiodinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Drgonova J, et al. Neuroscience, 2010 Feb 3. PMID 19819304, Free PMC Article
    2. Mouse brain localization of the protein kinase C-enhanced phosphatase 1 inhibitor KEPI (kinase C-enhanced PP1 inhibitor). Gong JP, et al. Neuroscience, 2005. PMID 15837133
    3. Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. Xiong L, et al. EBioMedicine, 2016 Jul. PMID 27333042, Free PMC Article
    4. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. Liu QR, et al. J Biol Chem, 2002 Apr 12. PMID 11812771
    5. The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus. McDermott JE, et al. BMC Syst Biol, 2016 Sep 23. PMID 27663205, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the data presented in this manuscript demonstrate a critical function of VPS35 in regulating PTH1R trafficking. This event and VPS35-interaction with PPP1R14C appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R-mediated catabolic response and bone remodeling.
      Title: Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response.
    2. regulation by morphine
      Title: KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
    3. The expression patterns point to possible roles for KEPI in regulating protein dephosphorylation by inhibiting PP1 activities in a number of brain pathways.
      Title: Mouse brain localization of the protein kinase C-enhanced phosphatase 1 inhibitor KEPI (kinase C-enhanced PP1 inhibitor).
    4. PPP1R14C gene encodes a PKC-potentiated inhibitory protein, KEPI, for type-1 Ser/Thr protein phosphatase (PP1). KEPI mRNA and protein are enriched in brain, heart and skeletal muscle.
      Title: KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 14C
    Names
    PKC-potentiated PP1 inhibitory protein
    kinase-enhanced PP1 inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133485.2 → NP_597844.1  protein phosphatase 1 regulatory subunit 14C

      See identical proteins and their annotated locations for NP_597844.1

      Status: VALIDATED

      Source sequence(s)
      AC155833, AC162384
      Consensus CDS
      CCDS56669.1
      UniProtKB/Swiss-Prot
      Q8R4S0
      Related
      ENSMUSP00000045110.6, ENSMUST00000043374.7
      Conserved Domains (1) summary
      pfam05361
      Location:70 → 164
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      3315974..3414975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245354.2 → XP_030101214.1  protein phosphatase 1 regulatory subunit 14C isoform X3

      Conserved Domains (1) summary
      pfam05361
      Location:70 → 140
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    2. XM_036156077.1 → XP_036011970.1  protein phosphatase 1 regulatory subunit 14C isoform X3

      Conserved Domains (1) summary
      pfam05361
      Location:70 → 140
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    3. XM_006512490.5 → XP_006512553.1  protein phosphatase 1 regulatory subunit 14C isoform X2

      Conserved Domains (1) summary
      pfam05361
      Location:70 → 158
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    4. XM_006512489.4 → XP_006512552.1  protein phosphatase 1 regulatory subunit 14C isoform X1

      Conserved Domains (1) summary
      pfam05361
      Location:70 → 182
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    5. XM_036156078.1 → XP_036011971.1  protein phosphatase 1 regulatory subunit 14C isoform X4

      UniProtKB/TrEMBL
      A0A1L1SRZ2
      Related
      ENSMUSP00000149688.2, ENSMUST00000217573.2
      Conserved Domains (1) summary
      pfam05361
      Location:70 → 125
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    6. XM_036156079.1 → XP_036011972.1  protein phosphatase 1 regulatory subunit 14C isoform X5

      Conserved Domains (1) summary
      pfam05361
      Location:58 → 124
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4S0.1 GenPept UniProtKB/Swiss-Prot:Q8R4S0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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