Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstz1provided by MGI
Official Full Name: glutathione transferase zeta 1 (maleylacetoacetate isomerase)provided by MGI
Primary source: MGI:MGI:1341859
See related: Ensembl:ENSMUSG00000021033 AllianceGenome:MGI:1341859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MAAI; GSTZ1-1
Summary: Predicted to enable glutathione transferase activity; maleylacetoacetate isomerase activity; and protein homodimerization activity. Predicted to be involved in L-phenylalanine catabolic process and glutathione metabolic process. Predicted to act upstream of or within tyrosine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 145.2), subcutaneous fat pad adult (RPKM 143.0) and 22 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12 D2; 12 41.34 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (87192102..87211497)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (87147161..87164723)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism
Title: Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism.
GSTZ1-1 deficiency may alter the metabolism of some drugs and xenobiotics.
Title: Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
glutathione S-transferase zeta/maleylacetoacetate isomerase is induced by C/EBPalpha and dependent on PPAR gamma
Title: C/EBPalpha-dependent induction of glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables maleylacetoacetate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables maleylacetoacetate isomerase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-phenylalanine catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tyrosine catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: maleylacetoacetate isomerase

Names: glutathione S-transferase zeta 1

NP_001239484.1

EC 2.5.1.18

EC 5.2.1.2

NP_001239485.1

EC 2.5.1.18

EC 5.2.1.2

NP_001351235.1

EC 2.5.1.18

EC 5.2.1.2

NP_001351236.1

EC 2.5.1.18

EC 5.2.1.2

NP_034493.1

EC 2.5.1.18

EC 5.2.1.2

XP_006515537.1

EC 2.5.1.18

EC 5.2.1.2

XP_006515538.1

EC 2.5.1.18

EC 5.2.1.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252555.1 → NP_001239484.1 maleylacetoacetate isomerase isoform 2

See identical proteins and their annotated locations for NP_001239484.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AA244513, AB041613, AK075927

Consensus CDS

CCDS88379.1

UniProtKB/TrEMBL

A0A1Y7VNC1, Q9JJA0

Related

ENSMUSP00000152343.2, ENSMUST00000222885.2

Conserved Domains (1) summary

TIGR01262
Location:1 → 156

maiA; maleylacetoacetate isomerase
NM_001252556.1 → NP_001239485.1 maleylacetoacetate isomerase isoform 2

See identical proteins and their annotated locations for NP_001239485.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AA244513, AK075927, BF722376, BY072664

Consensus CDS

CCDS88379.1

UniProtKB/TrEMBL

A0A1Y7VNC1, Q9JJA0

Related

ENSMUSP00000152321.2, ENSMUST00000220574.2

Conserved Domains (1) summary

TIGR01262
Location:1 → 156

maiA; maleylacetoacetate isomerase
NM_001364306.1 → NP_001351235.1 maleylacetoacetate isomerase isoform 3

Status: VALIDATED

Source sequence(s)

AC132609

Consensus CDS

CCDS88378.1

UniProtKB/TrEMBL

A0A1Y7VJZ2

Related

ENSMUSP00000152707.2, ENSMUST00000222222.2

Conserved Domains (1) summary

TIGR01262
Location:6 → 210

maiA; maleylacetoacetate isomerase
NM_001364307.1 → NP_001351236.1 maleylacetoacetate isomerase isoform 2

Status: VALIDATED

Source sequence(s)

AC132609

Consensus CDS

CCDS88379.1

UniProtKB/TrEMBL

A0A1Y7VNC1, Q9JJA0

Conserved Domains (1) summary

TIGR01262
Location:1 → 156

maiA; maleylacetoacetate isomerase
NM_010363.4 → NP_034493.1 maleylacetoacetate isomerase isoform 1

See identical proteins and their annotated locations for NP_034493.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AA244513, AK075927, BY072664

Consensus CDS

CCDS26071.1

UniProtKB/Swiss-Prot

Q9WVL0

Related

ENSMUSP00000053540.9, ENSMUST00000063117.10

Conserved Domains (3) summary

cd03191
Location:93 → 207

GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases

cd03042
Location:6 → 80

GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

TIGR01262
Location:7 → 211

maiA; maleylacetoacetate isomerase