Slamf6 SLAM family member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slamf6provided by MGI
Official Full Name: SLAM family member 6provided by MGI
Primary source: MGI:MGI:1353620
See related: Ensembl:ENSMUSG00000015314 AllianceGenome:MGI:1353620
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KAL1; NTBA; KAL1b; Ly108; NTB-A; SF2000
Summary: Involved in natural killer cell differentiation and natural killer cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SLAMF6 (SLAM family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 5.3), spleen adult (RPKM 3.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.54 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171745002..171776525)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171917458..171948958)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice.
Title: Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice.
Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions.
Title: Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions.
SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint.
Title: SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint.
Critical Role for SLAM/SAP Signaling in the Thymic Developmental Programming of IL-17- and IFN-gamma-Producing gammadelta T Cells.
Title: Critical Role for SLAM/SAP Signaling in the Thymic Developmental Programming of IL-17- and IFN-γ-Producing γδ T Cells.
Authors found that seSLAMF6 reduced activation-induced cell death and had an antiapoptotic effect on tumor-infiltrating lymphocytes.
Title: Soluble SLAMF6 Receptor Induces Strong CD8(+) T-cell Effector Function and Improves Anti-Melanoma Activity In Vivo.
naive T cells regulate B cell survival in a SLAMF6-dependent manner
Title: T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.
in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans
Title: Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.
CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.
Title: CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
Title: A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.
study establishes a central role for germinal center B cell-specific CD84 and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity
Title: B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Ly108 (e-PCR), detects polymorphism
- UniSTS:226176

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T-helper 17 cell lineage commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: SLAM family member 6

Names: lymphocyte antigen 108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347186.1 → NP_001334115.1 SLAM family member 6 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC091523, BC030031

Consensus CDS

CCDS83638.1

UniProtKB/Swiss-Prot

C6ESQ1, Q9ET39, Q9ET40

UniProtKB/TrEMBL

Q18PJ0, Q18PJ2

Related

ENSMUSP00000141448.2, ENSMUST00000195656.6
NM_001347187.1 → NP_001334116.1 SLAM family member 6 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC091523, EU591721

Consensus CDS

CCDS83639.1

UniProtKB/TrEMBL

Q18PJ2

Related

ENSMUSP00000141944.2, ENSMUST00000194561.2
NM_030710.3 → NP_109635.1 SLAM family member 6 isoform 1 precursor

See identical proteins and their annotated locations for NP_109635.1

Status: VALIDATED

Source sequence(s)

AC091523

Consensus CDS

CCDS15504.1

UniProtKB/TrEMBL

Q18PG5, Q18PJ2

Related

ENSMUSP00000130610.2, ENSMUST00000171330.7

Conserved Domains (1) summary

cl11960
Location:44 → 142

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

171745002..171776525

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496884.5 → XP_006496947.1 SLAM family member 6 isoform X1

UniProtKB/TrEMBL

Q18PJ2

Conserved Domains (1) summary

cl11960
Location:44 → 142

Ig; Immunoglobulin domain
XM_006496886.5 → XP_006496949.1 SLAM family member 6 isoform X2

UniProtKB/TrEMBL

Q18PJ2

Conserved Domains (1) summary

cl11960
Location:25 → 123

Ig; Immunoglobulin domain
XM_011238825.3 → XP_011237127.1 SLAM family member 6 isoform X3