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    Tusc3 tumor suppressor candidate 3 [ Mus musculus (house mouse) ]

    Gene ID: 80286, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tusc3provided by MGI
    Official Full Name
    tumor suppressor candidate 3provided by MGI
    Primary source
    MGI:MGI:1933134
    See related
    Ensembl:ENSMUSG00000118664 AllianceGenome:MGI:1933134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N33
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Located in mitochondrion. Is expressed in nervous system; neural retina; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 43.6), whole brain E14.5 (RPKM 27.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A4; 8 23.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (39472505..39620091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (39005351..39167050)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sarcoglycan zeta Neighboring gene STARR-seq mESC enhancer starr_21246 Neighboring gene STARR-seq mESC enhancer starr_21247 Neighboring gene predicted gene, 40493 Neighboring gene STARR-seq mESC enhancer starr_21248 Neighboring gene STARR-seq mESC enhancer starr_21249 Neighboring gene STARR-seq mESC enhancer starr_21250 Neighboring gene predicted gene, 23128 Neighboring gene STARR-seq mESC enhancer starr_21252 Neighboring gene STARR-seq mESC enhancer starr_21253 Neighboring gene STARR-positive B cell enhancer mm9_chr8:40240716-40241017 Neighboring gene MAD homolog 2 pseudogene Neighboring gene ribosomal protein L10A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Kelleher DJ, et al. Mol Cell, 2003 Jul. PMID 12887896
    2. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    3. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6989

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor suppressor candidate 3
    Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
    magnesium uptake/transporter TUSC3
    oligosaccharyl transferase subunit TUSC3
    putative prostate cancer tumor suppressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357304.1 → NP_001344233.1  tumor suppressor candidate 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC168314, AC174643
      Conserved Domains (1) summary
      pfam04756
      Location:45 → 215
      OST3_OST6; OST3 / OST6 family, transporter family

    2. NM_001357305.1 → NP_001344234.1  tumor suppressor candidate 3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC168314, AC174643
      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 312
      OST3_OST6; OST3 / OST6 family, transporter family

    3. NM_001357306.1 → NP_001344235.1  tumor suppressor candidate 3 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC168314, AC174643
      UniProtKB/TrEMBL
      A0A7N9VR83, Q8BMU5
      Related
      ENSMUSP00000159387.2, ENSMUST00000239509.1
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 342
      OST3_OST6; OST3 / OST6 family, transporter family

    4. NM_030254.4 → NP_084530.3  tumor suppressor candidate 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_084530.3

      Status: VALIDATED

      Source sequence(s)
      AK081223, AK132766, BC069898, BP765707
      Consensus CDS
      CCDS85529.1
      UniProtKB/Swiss-Prot
      Q8BTV1
      UniProtKB/TrEMBL
      Q8BMU5
      Related
      ENSMUSP00000159386.2, ENSMUST00000239508.1
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 342
      OST3_OST6; OST3 / OST6 family, transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      39472505..39620091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313026.3 → XP_017168515.1  tumor suppressor candidate 3 isoform X2

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 295
      OST3_OST6; OST3 / OST6 family, transporter family

    2. XM_017313027.3 → XP_017168516.1  tumor suppressor candidate 3 isoform X3

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 295
      OST3_OST6; OST3 / OST6 family, transporter family

    3. XM_017313024.3 → XP_017168513.1  tumor suppressor candidate 3 isoform X1

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 312
      OST3_OST6; OST3 / OST6 family, transporter family

    4. XM_036154388.1 → XP_036010281.1  tumor suppressor candidate 3 isoform X5

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:1 → 286
      OST3_OST6; OST3 / OST6 family, transporter family

    5. XM_017313028.2 → XP_017168517.1  tumor suppressor candidate 3 isoform X4

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:4 → 286
      OST3_OST6; OST3 / OST6 family, transporter family

    6. XM_036154387.1 → XP_036010280.1  tumor suppressor candidate 3 isoform X5

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:1 → 286
      OST3_OST6; OST3 / OST6 family, transporter family

    7. XM_017313029.2 → XP_017168518.1  tumor suppressor candidate 3 isoform X4

      UniProtKB/TrEMBL
      Q8BMU5
      Conserved Domains (1) summary
      pfam04756
      Location:4 → 286
      OST3_OST6; OST3 / OST6 family, transporter family

    RNA

    1. XR_004934902.1 RNA Sequence

    2. XR_004934901.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTV1.1 GenPept UniProtKB/Swiss-Prot:Q8BTV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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