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    Ssbp2 single-stranded DNA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 66970, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ssbp2provided by MGI
    Official Full Name
    single-stranded DNA binding protein 2provided by MGI
    Primary source
    MGI:MGI:1914220
    See related
    Ensembl:ENSMUSG00000003992 AllianceGenome:MGI:1914220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSDP2; Hspc116; 1500004K09Rik; 2310079I02Rik; 9330163K02Rik; A830008M03Rik
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; genitourinary system; and limb. Orthologous to human SSBP2 (single stranded DNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 14.2), whole brain E14.5 (RPKM 8.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 C3; 13 47.43 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (91608449..91854299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (91460305..91706175)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41014 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene Neighboring gene RIKEN cDNA A830009L08 gene Neighboring gene STARR-seq mESC enhancer starr_35251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:91510584-91510802 Neighboring gene STARR-seq mESC enhancer starr_35253 Neighboring gene STARR-positive B cell enhancer mm9_chr13:91600311-91600612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:91680694-91680899 Neighboring gene predicted gene, 41016 Neighboring gene STARR-positive B cell enhancer mm9_chr13:91775680-91775980 Neighboring gene STARR-positive B cell enhancer mm9_chr13:91776398-91776699 Neighboring gene STARR-seq mESC enhancer starr_35255 Neighboring gene RIKEN cDNA 4833422C13 gene Neighboring gene predicted gene, 22778 Neighboring gene STARR-seq mESC enhancer starr_35256 Neighboring gene acyl-CoA thioesterase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus. Steers NJ, et al. J Am Soc Nephrol, 2022 Jan. PMID 34893534, Free PMC Article
    2. Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response. Li J, et al. J Immunol, 2014 Nov 1. PMID 25238756, Free PMC Article
    3. SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability. Wang Y, et al. Oncogene, 2010 May 27. PMID 20348955, Free PMC Article
    4. Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. van Meyel DJ, et al. Development, 2003 May. PMID 12642495
    5. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Gu P, et al. Cell Res, 2013 May. PMID 23459151, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus.
      Title: GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus.
    2. The results uncovered a critical regulatory function for SSBP2 in hematopoietic stem and progenitor cells gene expression and function.
      Title: Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
    3. SSbp2 localizes to telomeres and participate in the repair of uncapped telomeres
      Title: Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    single-stranded DNA-binding protein 2
    Names
    sequence-specific single-stranded-DNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360775.2 → NP_001347704.1  single-stranded DNA-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154320, CT009700
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 346
      SSDP; Single-stranded DNA binding protein, SSDP

    2. NM_001360776.2 → NP_001347705.1  single-stranded DNA-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154320, CT009700
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:92 → 316
      SSDP; Single-stranded DNA binding protein, SSDP

    3. NM_024186.6 → NP_077148.1  single-stranded DNA-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_077148.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (1) lacks an internal segment, compared to isoform 2.
      Source sequence(s)
      AC154320, CT009700
      Consensus CDS
      CCDS26676.1
      UniProtKB/Swiss-Prot
      Q9CYZ8
      Related
      ENSMUSP00000037115.9, ENSMUST00000042122.15
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:92 → 308
      SSDP; Single-stranded DNA binding protein, SSDP

    4. NM_024272.5 → NP_077234.2  single-stranded DNA-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_077234.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes isoform 2.
      Source sequence(s)
      AC154320, CT009700
      Consensus CDS
      CCDS26677.1
      UniProtKB/Swiss-Prot
      B1B188, Q99LX9, Q9CYZ8
      UniProtKB/TrEMBL
      Q540I3
      Related
      ENSMUSP00000004094.9, ENSMUST00000004094.15
      Conserved Domains (2) summary
      smart00667
      Location:19 → 45
      LisH; Lissencephaly type-1-like homology motif
      pfam04503
      Location:83 → 338
      SSDP; Single-stranded DNA binding protein, SSDP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      91608449..91854299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247373.2 → XP_030103233.1  single-stranded DNA-binding protein 2 isoform X12

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 232
      SSDP; Single-stranded DNA binding protein, SSDP

    2. XM_030247371.2 → XP_030103231.1  single-stranded DNA-binding protein 2 isoform X11

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 240
      SSDP; Single-stranded DNA binding protein, SSDP

    3. XM_030247377.2 → XP_030103237.1  single-stranded DNA-binding protein 2 isoform X14

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 212
      SSDP; Single-stranded DNA binding protein, SSDP

    4. XM_030247376.2 → XP_030103236.1  single-stranded DNA-binding protein 2 isoform X13

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 220
      SSDP; Single-stranded DNA binding protein, SSDP

    5. XM_006517334.4 → XP_006517397.1  single-stranded DNA-binding protein 2 isoform X8

      Conserved Domains (1) summary
      pfam04503
      Location:38 → 301
      SSDP; Single-stranded DNA binding protein, SSDP

    6. XM_030247368.2 → XP_030103228.1  single-stranded DNA-binding protein 2 isoform X10

      Conserved Domains (1) summary
      pfam04503
      Location:47 → 271
      SSDP; Single-stranded DNA binding protein, SSDP

    7. XM_036158126.1 → XP_036014019.1  single-stranded DNA-binding protein 2 isoform X7

      Conserved Domains (1) summary
      pfam04503
      Location:64 → 319
      SSDP; Single-stranded DNA binding protein, SSDP

    8. XM_030247369.2 → XP_030103229.1  single-stranded DNA-binding protein 2 isoform X11

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 240
      SSDP; Single-stranded DNA binding protein, SSDP

    9. XM_030247372.2 → XP_030103232.1  single-stranded DNA-binding protein 2 isoform X11

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 240
      SSDP; Single-stranded DNA binding protein, SSDP

    10. XM_036158129.1 → XP_036014022.1  single-stranded DNA-binding protein 2 isoform X13

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 220
      SSDP; Single-stranded DNA binding protein, SSDP

    11. XM_030247375.2 → XP_030103235.1  single-stranded DNA-binding protein 2 isoform X12

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 232
      SSDP; Single-stranded DNA binding protein, SSDP

    12. XM_030247378.2 → XP_030103238.1  single-stranded DNA-binding protein 2 isoform X14

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 212
      SSDP; Single-stranded DNA binding protein, SSDP

    13. XM_030247367.2 → XP_030103227.1  single-stranded DNA-binding protein 2 isoform X9

      Conserved Domains (1) summary
      pfam04503
      Location:73 → 289
      SSDP; Single-stranded DNA binding protein, SSDP

    14. XM_011244554.2 → XP_011242856.1  single-stranded DNA-binding protein 2 isoform X6

      Conserved Domains (1) summary
      pfam04503
      Location:64 → 327
      SSDP; Single-stranded DNA binding protein, SSDP

    15. XM_036158130.1 → XP_036014023.1  single-stranded DNA-binding protein 2 isoform X14

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 212
      SSDP; Single-stranded DNA binding protein, SSDP

    16. XM_030247374.1 → XP_030103234.1  single-stranded DNA-binding protein 2 isoform X12

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 232
      SSDP; Single-stranded DNA binding protein, SSDP

    17. XM_036158127.1 → XP_036014020.1  single-stranded DNA-binding protein 2 isoform X11

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 240
      SSDP; Single-stranded DNA binding protein, SSDP

    18. XM_036158128.1 → XP_036014021.1  single-stranded DNA-binding protein 2 isoform X13

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 220
      SSDP; Single-stranded DNA binding protein, SSDP

    19. XM_036158131.1 → XP_036014024.1  single-stranded DNA-binding protein 2 isoform X14

      Conserved Domains (1) summary
      pfam04503
      Location:17 → 212
      SSDP; Single-stranded DNA binding protein, SSDP

    20. XM_030247370.2 → XP_030103230.1  single-stranded DNA-binding protein 2 isoform X11

      Conserved Domains (1) summary
      pfam04503
      Location:1 → 240
      SSDP; Single-stranded DNA binding protein, SSDP

    21. XM_036158125.1 → XP_036014018.1  single-stranded DNA-binding protein 2 isoform X3

      Conserved Domains (1) summary
      pfam04503
      Location:103 → 337
      SSDP; Single-stranded DNA binding protein, SSDP

    22. XM_006517328.5 → XP_006517391.1  single-stranded DNA-binding protein 2 isoform X1

      Conserved Domains (1) summary
      pfam04503
      Location:103 → 366
      SSDP; Single-stranded DNA binding protein, SSDP

    23. XM_006517329.4 → XP_006517392.1  single-stranded DNA-binding protein 2 isoform X2

      Conserved Domains (1) summary
      pfam04503
      Location:103 → 358
      SSDP; Single-stranded DNA binding protein, SSDP

    24. XM_006517332.5 → XP_006517395.1  single-stranded DNA-binding protein 2 isoform X5

      Conserved Domains (1) summary
      pfam04503
      Location:112 → 328
      SSDP; Single-stranded DNA binding protein, SSDP

    25. XM_011244553.4 → XP_011242855.1  single-stranded DNA-binding protein 2 isoform X4

      Conserved Domains (1) summary
      pfam04503
      Location:112 → 336
      SSDP; Single-stranded DNA binding protein, SSDP

    RNA

    1. XR_003950464.2 RNA Sequence

    2. XR_004938052.1 RNA Sequence

    3. XR_003950466.2 RNA Sequence

    4. XR_003950463.2 RNA Sequence

    5. XR_003950465.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYZ8.1 GenPept UniProtKB/Swiss-Prot:Q9CYZ8

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