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    Hpcal1 hippocalcin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 53602, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hpcal1provided by MGI
    Official Full Name
    hippocalcin-like 1provided by MGI
    Primary source
    MGI:MGI:1855689
    See related
    Ensembl:ENSMUSG00000071379 AllianceGenome:MGI:1855689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nvp3; NVL-3; NVP-3; Vnsl3; Vsnl3; VILIP3
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; ganglia; and retina layer. Orthologous to human HPCAL1 (hippocalcin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 64.1), lung adult (RPKM 42.5) and 27 other tissues See more
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    Genomic context

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    Location:
    12 A1.2; 12 8.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17740810..17841943)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17690750..17791944)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36862 Neighboring gene predicted gene, 29864 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:17733384-17733567 Neighboring gene STARR-seq mESC enhancer starr_31667 Neighboring gene predicted gene, 51995 Neighboring gene STARR-seq mESC enhancer starr_31670 Neighboring gene predicted gene, 40312 Neighboring gene STARR-seq mESC enhancer starr_31671 Neighboring gene predicted gene 9222 Neighboring gene predicted gene, 51520

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling. Chen T, et al. Theranostics, 2022. PMID 36438486, Free PMC Article
    2. Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner. Oikawa K, et al. J Biol Chem, 2004 Apr 9. PMID 14739275
    3. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
    4. DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. Kannan K, et al. Oncogene, 2001 Jun 7. PMID 11423996
    5. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling.
      Title: Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling.
    2. visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner
      Title: Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hippocalcin-like protein 1
    Names
    neural visinin-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361645.1 → NP_001348574.1  hippocalcin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC138342, AC154636
      Consensus CDS
      CCDS25830.1
      UniProtKB/Swiss-Prot
      P35333, P62748
      UniProtKB/TrEMBL
      E9PV73
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001422995.1 → NP_001409924.1  hippocalcin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC138342, AC154636
      UniProtKB/Swiss-Prot
      P35333, P62748

    3. NM_001422996.1 → NP_001409925.1  hippocalcin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC138342, AC154636
      UniProtKB/Swiss-Prot
      P35333, P62748

    4. NM_001422997.1 → NP_001409926.1  hippocalcin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC138342, AC154636
      UniProtKB/Swiss-Prot
      P35333, P62748

    5. NM_001422998.1 → NP_001409927.1  hippocalcin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC138342, AC154636
      UniProtKB/Swiss-Prot
      P35333, P62748

    6. NM_016677.5 → NP_057886.1  hippocalcin-like protein 1

      See identical proteins and their annotated locations for NP_057886.1

      Status: VALIDATED

      Source sequence(s)
      AC138342, AC154636
      Consensus CDS
      CCDS25830.1
      UniProtKB/Swiss-Prot
      P35333, P62748
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000071756.4, ENSMUST00000071858.5
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17740810..17841943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246812.2 → XP_030102672.1  hippocalcin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P35333, P62748
      UniProtKB/TrEMBL
      E9PV73
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_006515157.3 → XP_006515220.1  hippocalcin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515220.1

      UniProtKB/Swiss-Prot
      P35333, P62748
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000152772.2, ENSMUST00000222944.2
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_030246819.2 → XP_030102679.1  hippocalcin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P35333, P62748
      UniProtKB/TrEMBL
      E9PV73
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62748.2 GenPept UniProtKB/Swiss-Prot:P62748

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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