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    Asb13 ankyrin repeat and SOCS box-containing 13 [ Mus musculus (house mouse) ]

    Gene ID: 142688, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Asb13provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 13provided by MGI
    Primary source
    MGI:MGI:2145525
    See related
    Ensembl:ENSMUSG00000033781 AllianceGenome:MGI:2145525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-13; 2210015B19Rik; 6430573K02Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human ASB13 (ankyrin repeat and SOCS box containing 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 25.8), liver adult (RPKM 18.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A1; 13 2.03 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (3683589..3703822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (3633589..3653822)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene GDP dissociation inhibitor 2 Neighboring gene transcription activation suppressor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E9151 Neighboring gene STARR-seq mESC enhancer starr_33488 Neighboring gene STARR-seq mESC enhancer starr_33489 Neighboring gene general transcription factor II A, 2 pseudogene Neighboring gene predicted gene, 35190 Neighboring gene VISTA enhancer mm41 Neighboring gene STARR-seq mESC enhancer starr_33491 Neighboring gene STARR-seq mESC enhancer starr_33492 Neighboring gene STARR-seq mESC enhancer starr_33493 Neighboring gene predicted gene, 53803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 13
    Names
    ankyrin repeat and SOCS box-containing protein 13
    ankyrin repeat domain-containing SOCS box protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267724.1 → NP_001254653.1  ankyrin repeat and SOCS box protein 13 isoform 3

      See identical proteins and their annotated locations for NP_001254653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC129597, BG080214
      Conserved Domains (3) summary
      cd00204
      Location:15 → 79
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13857
      Location:22 → 76
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:36 → 66
      ANK; ANK repeat [structural motif]

    2. NM_178283.4 → NP_840068.1  ankyrin repeat and SOCS box protein 13 isoform 1

      See identical proteins and their annotated locations for NP_840068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC129597, AK078289
      Consensus CDS
      CCDS36582.1
      UniProtKB/Swiss-Prot
      Q8VBX0
      Related
      ENSMUSP00000046476.7, ENSMUST00000042288.8
      Conserved Domains (4) summary
      cd00204
      Location:46 → 170
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03729
      Location:237 → 278
      SOCS_ASB13; SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
      sd00045
      Location:119 → 147
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:152 → 202
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      3683589..3703822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003950427.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBX0.1 GenPept UniProtKB/Swiss-Prot:Q8VBX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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