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    Coro2b coronin, actin binding protein, 2B [ Mus musculus (house mouse) ]

    Gene ID: 235431, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Coro2bprovided by MGI
    Official Full Name
    coronin, actin binding protein, 2Bprovided by MGI
    Primary source
    MGI:MGI:2444283
    See related
    Ensembl:ENSMUSG00000041729 AllianceGenome:MGI:2444283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLIPINC; E130012P22Rik
    Summary
    Predicted to enable actin filament binding activity; talin binding activity; and vinculin binding activity. Acts upstream of or within focal adhesion assembly; negative regulation of stress fiber assembly; and regulation of glomerular filtration. Located in focal adhesion. Is expressed in cerebral cortex; dorsal root ganglion; and hippocampus. Orthologous to human CORO2B (coronin 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 45.9), cortex adult (RPKM 26.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coro2b in Genome Data Viewer
    Location:
    9 B; 9 33.71 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62326770..62444326, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62419490..62537044, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40522 Neighboring gene STARR-seq mESC enhancer starr_24378 Neighboring gene VISTA enhancer mm210 Neighboring gene predicted gene, 40523 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:62336692-62336845 Neighboring gene STARR-positive B cell enhancer ABC_E1788 Neighboring gene predicted gene, 39352 Neighboring gene predicted gene, 53532

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. Chen Y, et al. FEBS Lett, 2020 Sep. PMID 32692409
    2. Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition. Chen Y, et al. J Neurosci, 2023 Jan 11. PMID 36639906, Free PMC Article
    3. Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement. Schwarz A, et al. Sci Rep, 2019 Jun 20. PMID 31221975, Free PMC Article
    4. Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Xu B, et al. Cell, 2013 Jan 17. PMID 23332760, Free PMC Article
    5. Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis. Gobé C, et al. PLoS Genet, 2019 Feb. PMID 30735494, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
      Title: Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
    2. Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.
      Title: Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.
    3. CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation.
      Title: The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables talin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables vinculin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coronin-2B
    Names
    E130012P22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175484.3 → NP_780693.2  coronin-2B

      See identical proteins and their annotated locations for NP_780693.2

      Status: VALIDATED

      Source sequence(s)
      AK087414, BB647296, BC062649
      Consensus CDS
      CCDS23264.2
      UniProtKB/Swiss-Prot
      Q6P5U9, Q8BH44
      Related
      ENSMUSP00000041826.6, ENSMUST00000048043.12
      Conserved Domains (2) summary
      sd00039
      Location:45 → 85
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:15 → 460
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      62326770..62444326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511100.4 → XP_006511163.1  coronin-2B isoform X3

      See identical proteins and their annotated locations for XP_006511163.1

      UniProtKB/Swiss-Prot
      Q8BH44
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 455
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006511094.5 → XP_006511157.3  coronin-2B isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:65 → 105
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:35 → 480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_036154902.1 → XP_036010795.1  coronin-2B isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 455
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_006511099.5 → XP_006511162.1  coronin-2B isoform X3

      See identical proteins and their annotated locations for XP_006511162.1

      UniProtKB/Swiss-Prot
      Q8BH44
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 455
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_006511097.5 → XP_006511160.1  coronin-2B isoform X3

      See identical proteins and their annotated locations for XP_006511160.1

      UniProtKB/Swiss-Prot
      Q8BH44
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 455
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_006511098.5 → XP_006511161.1  coronin-2B isoform X3

      See identical proteins and their annotated locations for XP_006511161.1

      UniProtKB/Swiss-Prot
      Q8BH44
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 455
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_006511095.3 → XP_006511158.1  coronin-2B isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:43 → 83
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:13 → 458
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH44.2 GenPept UniProtKB/Swiss-Prot:Q8BH44

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