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    Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68652, updated on 12-Mar-2024

    Summary

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    Official Symbol
    Tab2provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by MGI
    Primary source
    MGI:MGI:1915902
    See related
    Ensembl:ENSMUSG00000015755 AllianceGenome:MGI:1915902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein kinase activity; and response to lipopolysaccharide. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.4), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tab2 in Genome Data Viewer
    Location:
    10 A1; 10 2.56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7781412..7832039, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7905648..7956255, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7559346-7559529 Neighboring gene STARR-seq mESC enhancer starr_25692 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726 Neighboring gene STARR-seq mESC enhancer starr_25693 Neighboring gene STARR-seq mESC enhancer starr_25694 Neighboring gene predicted gene, 30820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7785616-7785813 Neighboring gene STARR-seq mESC enhancer starr_25695 Neighboring gene STARR-seq mESC enhancer starr_25696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7904647-7904800 Neighboring gene predicted gene, 30906 Neighboring gene uronyl-2-sulfotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High glucose induced-macrophage activation through TGF-β-activated kinase 1 signaling pathway. Xu X, et al. Inflamm Res, 2016 Aug. PMID 27153994
    2. Expression analysis of the TAB2 protein in adult mouse tissues. Orelio C, et al. Inflamm Res, 2007 Mar. PMID 17406806, Free PMC Article
    3. MiR-142a-3p alleviates Escherichia coli derived lipopolysaccharide-induced acute lung injury by targeting TAB2. Yang Y, et al. Microb Pathog, 2019 Nov. PMID 31494298
    4. MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 upon lipopolysaccharide stimulation. Sul OJ, et al. Bone, 2018 Nov. PMID 30144578
    5. Activated macrophage survival is coordinated by TAK1 binding proteins. Mihaly SR, et al. PLoS One, 2014. PMID 24736749, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
      Title: Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
    2. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB activation and the innate immune response.
      Title: The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.
    3. TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.
      Title: TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.
    4. TET2 promotes IL-1beta expression in J774.1 cell through TLR4/MAPK signaling pathway with demethylation of TAB2 promoter.
      Title: TET2 promotes IL-1β expression in J774.1 cell through TLR4/MAPK signaling pathway with demethylation of TAB2 promoter.
    5. miR-142-3p was up-regulated both in lipopolysaccharide-induced acute lung Injury mice model and RAW264.7cells model. MiR-142a-3p mimics group experienced significant decrease in the secretion of pro-inflammatory cytokines as a result of the inhibition of NF-kappaB signaling pathway. Bioinformatics database showed that the adaptor protein, TAB2, was critical in this pathway and it is the target gene of miR-142a-3p.
      Title: MiR-142a-3p alleviates Escherichia coli derived lipopolysaccharide-induced acute lung injury by targeting TAB2.
    6. Lipopolysaccharide-induced miR-155 promoted autophagy to increase osteoclast formation via decreased TAB2.
      Title: MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 upon lipopolysaccharide stimulation.
    7. These findings support a regulatory role for TGF-beta-activated kinase 1 in governing downstream MAPKs/NF-kappaB signaling cascades in the macrophage activation in response to hyperglycemic insult
      Title: High glucose induced-macrophage activation through TGF-β-activated kinase 1 signaling pathway.
    8. RNF4 negatively regulates NF-kappaB signaling by down-regulating TAB2
      Title: RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
    9. TAB1 and TAB2 are required for activated macrophages, making TAB1 and TAB2 effective targets to control inflammation by modulating macrophage survival.
      Title: Activated macrophage survival is coordinated by TAK1 binding proteins.
    10. Loss of Tab2 is associated with liver injury.
      Title: TAK1 binding protein 2 is essential for liver protection from stressors.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Names
    TGF-beta-activated kinase 1-binding protein 2
    Tak1 binding protein 2
    mitogen-activated protein kinase kinase kinase 7-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359534.1 → NP_001346463.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      AC092856, AW492243, AY093701, CN532534
      Consensus CDS
      CCDS23691.1
      UniProtKB/Swiss-Prot
      Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. NM_138667.3 → NP_619608.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      See identical proteins and their annotated locations for NP_619608.1

      Status: VALIDATED

      Source sequence(s)
      AC092856, AK003993, AY093701, BF468714, BG078791, BY429748, CK391470
      Consensus CDS
      CCDS23691.1
      UniProtKB/Swiss-Prot
      Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
      Related
      ENSMUSP00000121266.2, ENSMUST00000146444.8
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      7781412..7832039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243204.4 → XP_011241506.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241506.1

      Conserved Domains (4) summary
      smart00547
      Location:693 → 716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563 → 640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694 → 713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. XM_011243203.4 → XP_011241505.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241505.1

      Conserved Domains (4) summary
      smart00547
      Location:693 → 716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563 → 640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694 → 713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    3. XM_030245247.2 → XP_030101107.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (4) summary
      smart00547
      Location:693 → 716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563 → 640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694 → 713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    4. XM_036155973.1 → XP_036011866.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (4) summary
      smart00547
      Location:693 → 716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:563 → 640
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:694 → 713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    5. XM_036155974.1 → XP_036011867.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      TIGR04523
      Location:537 → 614
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    6. XM_036155977.1 → XP_036011870.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      D3Z216
      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

    7. XM_036155976.1 → XP_036011869.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      D3Z216
      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

    8. XM_036155975.1 → XP_036011868.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      D3Z216
      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K90.1 GenPept UniProtKB/Swiss-Prot:Q99K90

    Gene LinkOut

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