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    Mgst1 microsomal glutathione S-transferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 56615, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mgst1provided by MGI
    Official Full Name
    microsomal glutathione S-transferase 1provided by MGI
    Primary source
    MGI:MGI:1913850
    See related
    Ensembl:ENSMUSG00000008540 AllianceGenome:MGI:1913850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gst; 1500002K10Rik
    Summary
    Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human MGST1 (microsomal glutathione S-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 1165.6), liver E18 (RPKM 396.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mgst1 in Genome Data Viewer
    Location:
    6 G1; 6 68.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (138117525..138133753)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (138140527..138156755)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38552 Neighboring gene STARR-seq mESC enhancer starr_17634 Neighboring gene STARR-seq mESC enhancer starr_17635 Neighboring gene solute carrier family 15, member 5 Neighboring gene STARR-positive B cell enhancer mm9_chr6:138096406-138096707 Neighboring gene predicted gene, 30213 Neighboring gene RIKEN cDNA A830011K09 gene Neighboring gene LIM domain only 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. Mavis CK, et al. Prostate, 2009 Sep 1. PMID 19444856, Free PMC Article
    2. Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression. Kelner MJ, et al. Biochim Biophys Acta, 2004 May 25. PMID 15157743
    3. Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Maeda A, et al. Biochemistry, 2005 Jan 18. PMID 15641772, Free PMC Article
    4. Cloning, characterisation and bacterial expression of full length cDNA for the mouse liver microsomal glutathione S-transferase. Raza H, et al. Oncol Rep, 2000 May-Jun. PMID 10767383
    5. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Bräutigam L, et al. Redox Biol, 2018 Jul. PMID 29702404, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.
      Title: A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.
    2. The impact of MGST1 on hematopoiesis was also shown in hematopoietic stem/progenitor cells (HSPC) isolated from mice, where it was expressed at high levels. Upon promoting HSPC differentiation, lentiviral shRNA MGST1 knockdown significantly reduced differentiated, dedicated cells of the hematopoietic system.
      Title: MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.
    3. Gst genes are extensively downregulated in primary but not metastatic TRAMP tumors.
      Title: Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors.
    4. MGST1 is a dominant, highly expressed enzyme in mouse retinal pigment epithelium (RPE) microsomes that displays an important protective function against oxidative insult in the RPE that decreases with age.
      Title: Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging.
    5. identification of the promoter region and a comprehensive examination of tissue expression of MGST1
      Title: Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipid hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microsomal glutathione S-transferase 1
    Names
    microsomal GST-1
    microsomal GST-I
    NP_001334418.1
    NP_001348236.1
    NP_001348237.1
    NP_001348238.1
    NP_064330.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347489.2 → NP_001334418.1  microsomal glutathione S-transferase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences result in translation from an alternate start codon. The encoded isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS85177.1
      UniProtKB/TrEMBL
      E9QJW0
      Related
      ENSMUSP00000112923.2, ENSMUST00000118091.8

    2. NM_001361307.1 → NP_001348236.1  microsomal glutathione S-transferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS90131.1
      UniProtKB/TrEMBL
      D3YU60
      Related
      ENSMUSP00000112646.2, ENSMUST00000120939.8

    3. NM_001361308.1 → NP_001348237.1  microsomal glutathione S-transferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS20668.1
      UniProtKB/Swiss-Prot
      Q91VS7, Q9CQ57, Q9R191
      UniProtKB/TrEMBL
      Q53ZD4
      Related
      ENSMUSP00000113257.2, ENSMUST00000120302.8
      Conserved Domains (1) summary
      pfam01124
      Location:19 → 150
      MAPEG; MAPEG family

    4. NM_001361309.1 → NP_001348238.1  microsomal glutathione S-transferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS20668.1
      UniProtKB/Swiss-Prot
      Q91VS7, Q9CQ57, Q9R191
      UniProtKB/TrEMBL
      Q53ZD4
      Related
      ENSMUSP00000113859.2, ENSMUST00000120230.8
      Conserved Domains (1) summary
      pfam01124
      Location:19 → 150
      MAPEG; MAPEG family

    5. NM_019946.5 → NP_064330.2  microsomal glutathione S-transferase 1 isoform 1

      See identical proteins and their annotated locations for NP_064330.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AC121849, AC131766, AK005122
      Consensus CDS
      CCDS20668.1
      UniProtKB/Swiss-Prot
      Q91VS7, Q9CQ57, Q9R191
      UniProtKB/TrEMBL
      Q53ZD4
      Related
      ENSMUSP00000008684.5, ENSMUST00000008684.11
      Conserved Domains (1) summary
      pfam01124
      Location:19 → 150
      MAPEG; MAPEG family

    RNA

    1. NR_154597.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766

    2. NR_154598.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Related
      ENSMUST00000140932.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      138117525..138133753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VS7.3 GenPept UniProtKB/Swiss-Prot:Q91VS7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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