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    Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [ Mus musculus (house mouse) ]

    Gene ID: 68501, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nsmce2provided by MGI
    Official Full Name
    NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligaseprovided by MGI
    Primary source
    MGI:MGI:1915751
    See related
    Ensembl:ENSMUSG00000059586 AllianceGenome:MGI:1915751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110014D18Rik
    Summary
    Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to act upstream of or within DNA recombination; DNA repair; and cell division. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in brain; spermatocyte; and testis. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.9), placenta adult (RPKM 4.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D1; 15 25.19 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (59246047..59473538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (59374198..59601689)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene squalene epoxidase Neighboring gene WASH complex subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E8593 Neighboring gene STARR-seq mESC enhancer starr_38785 Neighboring gene STARR-seq mESC enhancer starr_38787 Neighboring gene STARR-seq mESC enhancer starr_38788 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59356284-59356467 Neighboring gene STARR-seq mESC enhancer starr_38791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59403555-59403708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59429020-59429203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59429225-59429438 Neighboring gene STARR-seq mESC enhancer starr_38794 Neighboring gene STARR-seq mESC enhancer starr_38795 Neighboring gene STARR-positive B cell enhancer ABC_E7372 Neighboring gene predicted gene, 36677 Neighboring gene STARR-seq mESC enhancer starr_38797 Neighboring gene tribbles pseudokinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis. Berkholz J, et al. J Cell Sci, 2014 Sep 1. PMID 25002400
    2. SUMO E3 ligase HIGH PLOIDY2 regulates endocycle onset and meristem maintenance in Arabidopsis. Ishida T, et al. Plant Cell, 2009 Aug. PMID 19666737, Free PMC Article
    3. NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. Jacome A, et al. EMBO J, 2015 Nov 3. PMID 26443207, Free PMC Article
    4. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Hwang G, et al. Development, 2017 May 1. PMID 28302748, Free PMC Article
    5. Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. Gur I, et al. PLoS One, 2014. PMID 24911587, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation.
      Title: NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase NSE2
    Names
    E3 SUMO-protein transferase NSE2
    MMS21 homolog
    non-SMC element 2 homolog (MMS21, S. cerevisiae)
    non-structural maintenance of chromosomes element 2 homolog
    NP_001158076.1
    NP_001361697.1
    NP_081022.2
    XP_006521380.1
    XP_017172226.1
    XP_030104584.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164604.1 → NP_001158076.1  E3 SUMO-protein ligase NSE2 isoform 2

      See identical proteins and their annotated locations for NP_001158076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK051277, BE991399, DV057668
      Consensus CDS
      CCDS49611.1
      UniProtKB/Swiss-Prot
      Q91VT1
      Related
      ENSMUSP00000128893.2, ENSMUST00000168722.3

    2. NM_001374768.1 → NP_001361697.1  E3 SUMO-protein ligase NSE2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107764, AC113269, AC161172
      Consensus CDS
      CCDS88769.1
      UniProtKB/TrEMBL
      A0A2I3BS18
      Related
      ENSMUSP00000154811.2, ENSMUST00000227173.2
      Conserved Domains (1) summary
      cd16651
      Location:193 → 262
      SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

    3. NM_026746.3 → NP_081022.2  E3 SUMO-protein ligase NSE2 isoform 1

      See identical proteins and their annotated locations for NP_081022.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AK003685, AW489283, DV057668
      Consensus CDS
      CCDS27498.1
      UniProtKB/Swiss-Prot
      Q8BQ88, Q91VT1, Q9D1D3
      Related
      ENSMUSP00000078641.4, ENSMUST00000079703.11
      Conserved Domains (1) summary
      pfam11789
      Location:156 → 216
      zf-Nse; Zinc-finger of the MIZ type in Nse subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      59246047..59473538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316737.3 → XP_017172226.1  E3 SUMO-protein ligase NSE2 isoform X2

      Conserved Domains (1) summary
      cl17238
      Location:182 → 231
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_030248724.2 → XP_030104584.1  E3 SUMO-protein ligase NSE2 isoform X3

      Conserved Domains (1) summary
      cl17238
      Location:156 → 205
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_006521317.5 → XP_006521380.1  E3 SUMO-protein ligase NSE2 isoform X1

      Conserved Domains (1) summary
      cd16651
      Location:192 → 261
      SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VT1.1 GenPept UniProtKB/Swiss-Prot:Q91VT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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