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    Nasp nuclear autoantigenic sperm protein (histone-binding) [ Mus musculus (house mouse) ]

    Gene ID: 50927, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Naspprovided by MGI
    Official Full Name
    nuclear autoantigenic sperm protein (histone-binding)provided by MGI
    Primary source
    MGI:MGI:1355328
    See related
    Ensembl:ENSMUSG00000028693 AllianceGenome:MGI:1355328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epcs32; Nasp-T; D4Ertd767e; 5033430J04Rik
    Summary
    Enables histone binding activity. Involved in G1/S transition of mitotic cell cycle; blastocyst development; and histone exchange. Acts upstream of or within DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; extraembryonic component; lung; metanephros; and rest of cerebellum marginal layer. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 97.7), testis adult (RPKM 45.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 53.24 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116458249..116488894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116601052..116628676, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11140 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene RIKEN cDNA C530005A16 gene Neighboring gene coiled-coil domain containing 17 Neighboring gene STARR-positive B cell enhancer ABC_E4648 Neighboring gene STARR-positive B cell enhancer ABC_E4649 Neighboring gene STARR-positive B cell enhancer ABC_E7980 Neighboring gene aldo-keto reductase family 1, member A1 Neighboring gene predicted gene, 25137

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A]. Zhang Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2022 Jul. PMID 35786450
    2. A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse. Zhang J, et al. Mediators Inflamm, 2021. PMID 34720750, Free PMC Article
    3. A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus. Ju J, et al. Front Immunol, 2019. PMID 31001259, Free PMC Article
    4. Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells. Richardson RT, et al. Gene, 2006 Apr 12. PMID 16423470
    5. Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei. Alekseev OM, et al. J Biol Chem, 2005 Jan 28. PMID 15533935

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway.
      Title: sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway.
    2. [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A].
      Title: [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A].
    3. A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
      Title: A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
    4. A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus.
      Title: A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus.
    5. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
      Title: MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
    6. NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation; therefore, tNASP's role is to provide the functional link between linker histones and cell cycle progression during meiosis.
      Title: Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.
    7. in the cytoplasm linker histones are bound to a complex containing NASP and HSP90 whose ATPase activity is stimulated by binding NASP
      Title: Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei.
    8. NASP and the linker histones are key players in the assembly of chromatin after DNA replication
      Title: Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation.
    9. overexpression affects progression through cell cycle
      Title: Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle.
    10. Sp1 and Ets are the primary activators of the NASP promoter.
      Title: Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear autoantigenic sperm protein
    Names
    somatic histone binding protein NASP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081475.1 → NP_001074944.1  nuclear autoantigenic sperm protein isoform 1

      See identical proteins and their annotated locations for NP_001074944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
      Source sequence(s)
      AK083333, AL669953
      Consensus CDS
      CCDS38852.1
      UniProtKB/TrEMBL
      B1AU76
      Related
      ENSMUSP00000030457.6, ENSMUST00000030457.12
      Conserved Domains (3) summary
      sd00006
      Location:203 → 231
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:201 → 277
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:203 → 240
      SHNi-TPR

    2. NM_001284229.1 → NP_001271158.1  nuclear autoantigenic sperm protein isoform 3

      See identical proteins and their annotated locations for NP_001271158.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
      Source sequence(s)
      AF095722, AK083333, AL669953
      Consensus CDS
      CCDS71451.1
      UniProtKB/Swiss-Prot
      Q99MD9
      Related
      ENSMUSP00000079946.5, ENSMUST00000081182.5
      Conserved Domains (3) summary
      sd00006
      Location:176 → 204
      TPR; TPR repeat [structural motif]
      pfam10516
      Location:176 → 213
      SHNi-TPR; SHNi-TPR
      pfam13424
      Location:173 → 250
      TPR_12; Tetratricopeptide repeat

    3. NM_016777.3 → NP_058057.3  nuclear autoantigenic sperm protein isoform 2

      See identical proteins and their annotated locations for NP_058057.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AL669953, BX004835
      Consensus CDS
      CCDS18513.1
      UniProtKB/Swiss-Prot
      O35499, O88993, Q3V150, Q99KE9, Q99MD9
      UniProtKB/TrEMBL
      B1AU75
      Related
      ENSMUSP00000030456.8, ENSMUST00000030456.14
      Conserved Domains (4) summary
      TIGR00927
      Location:250 → 505
      2A1904; K+-dependent Na+/Ca+ exchanger
      sd00006
      Location:528 → 556
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:526 → 602
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:528 → 565
      SHNi-TPR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116458249..116488894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253656.2 → XP_030109516.1  nuclear autoantigenic sperm protein isoform X1

      UniProtKB/Swiss-Prot
      O35499, O88993, Q3V150, Q99KE9, Q99MD9
      UniProtKB/TrEMBL
      B1AU75
      Conserved Domains (4) summary
      TIGR00927
      Location:250 → 505
      2A1904; K+-dependent Na+/Ca+ exchanger
      sd00006
      Location:528 → 556
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:526 → 602
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:528 → 565
      SHNi-TPR
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MD9.2 GenPept UniProtKB/Swiss-Prot:Q99MD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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