Retn resistin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Retnprovided by MGI
Official Full Name: resistinprovided by MGI
Primary source: MGI:MGI:1888506
See related: Ensembl:ENSMUSG00000012705 AllianceGenome:MGI:1888506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADSF; Rstn; Xcp4; Fizz3
Summary: Predicted to enable hormone activity. Predicted to be involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Is expressed in adipose tissue; gonadal fat pad; inguinal fat pad; renal fat pad; and white fat. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 408.3), mammary gland adult (RPKM 151.5) and 2 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3705770..3709818)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3655770..3659818)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases.
Title: Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases.
Resistin deletion protects against heart failure injury by targeting DNA damage response.
Title: Resistin deletion protects against heart failure injury by targeting DNA damage response.
Is resistin the master link between inflammation and inflammation-related chronic diseases?
Title: Is resistin the master link between inflammation and inflammation-related chronic diseases?
Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1alpha Signaling Pathway in Male NAFLD Mice.
Title: Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice.
Resistin is co-secreted with adiponectin in white mouse adipocytes.
Title: Resistin is co-secreted with adiponectin in white mouse adipocytes.
Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
Title: Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
Lmo4-resistin signaling contributes to adipose tissue-liver crosstalk upon weight cycling.
Title: Lmo4-resistin signaling contributes to adipose tissue-liver crosstalk upon weight cycling.
These findings parse a role for Ca(2+) in resistin transactivation and provide support that manipulation of Serca2a-NFATc-Resistin axis might.
Title: A role for calcium in resistin transcriptional activation in diabetic hearts.
DNA methylation of adiponectin and resistin is affected by short chain fatty acids in a high fat diet
Title: Effects of SCFA on the DNA methylation pattern of adiponectin and resistin in high-fat-diet-induced obese male mice.
Resistin and TLR4 are part of a new regulatory pathway of neuronal autophagy.
Title: Resistin inhibits neuronal autophagy through Toll-like receptor 4.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

Go to the top of the page Help

Markers

Retn (e-PCR), detects polymorphism
- UniSTS:547568

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of progesterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: resistin

Names: adipose tissue-specific secretory factor; adipose-specific cysteine-rich secreted protein A12-alpha; cysteine-rich secreted protein FIZZ3; dominant inhibitory adipocyte-specific secretory factor; found in inflammatory zone 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204959.1 → NP_001191888.1 resistin precursor

See identical proteins and their annotated locations for NP_001191888.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK131613, BC051196

Consensus CDS

CCDS22068.1

UniProtKB/Swiss-Prot

Q99P87

UniProtKB/TrEMBL

Q3V2F6, Q5BMX4

Related

ENSMUSP00000012849.9, ENSMUST00000012849.15

Conserved Domains (1) summary

pfam06954
Location:26 → 110

Resistin
NM_022984.4 → NP_075360.1 resistin precursor

See identical proteins and their annotated locations for NP_075360.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF510100

Consensus CDS

CCDS22068.1

UniProtKB/Swiss-Prot

Q99P87

UniProtKB/TrEMBL

Q3V2F6, Q5BMX4

Related

ENSMUSP00000133024.3, ENSMUST00000169234.3

Conserved Domains (1) summary

pfam06954
Location:26 → 110

Resistin