Zbtb1 zinc finger and BTB domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb1provided by MGI
Official Full Name: zinc finger and BTB domain containing 1provided by MGI
Primary source: MGI:MGI:2442326
See related: Ensembl:ENSMUSG00000033454 AllianceGenome:MGI:2442326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bsg2; 9430077A12; C430003J21Rik
Summary: Enables protein homodimerization activity. Involved in positive regulation of T cell mediated immunity; positive regulation of lymphocyte differentiation; and thymus development. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Predicted to be located in centrosome; nuclear body; and nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cerebral cortex; female reproductive system; trigeminal ganglion; and urinary system. Orthologous to human ZBTB1 (zinc finger and BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 4.3), ovary adult (RPKM 4.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 33.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (76416825..76443729)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (76370051..76396955)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA and circRNA Expression Analysis in a Zbtb1 Gene Knockout Monoclonal EL4 Cell Line.
Title: MicroRNA and circRNA Expression Analysis in a Zbtb1 Gene Knockout Monoclonal EL4 Cell Line.
these results show that Zbtb1 expression prevents activation of a default myeloid program in LMPP cells, ensuring the generation of lymphoid cells
Title: Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors.
these results indicate that Zbtb1 prevents DNA damage in replicating immune progenitors, allowing the generation of B cells, T cells, and myeloid cells.
Title: Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors.
Expression of mRNA encoding transgenic Zbtb1, a predicted transcription repressor, is greatest in hematopoietic stem cells, thymocytes, and pre-B cells, highlighting its essential role in lymphoid development
Title: Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development.
Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.
Title: ZBTB1 is a determinant of lymphoid development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136045 (e-PCR)
- UniSTS:210040

Zbtb1 (e-PCR), detects polymorphism
- UniSTS:515988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell mediated immunity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pro-T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 1

Names: brain specific protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364323.1 → NP_001351252.1 zinc finger and BTB domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC124453

UniProtKB/TrEMBL

Q3V277

Conserved Domains (3) summary

sd00017
Location:536 → 574

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

pfam13465
Location:592 → 617

zf-H2C2_2; Zinc-finger double domain
NM_178744.3 → NP_848859.1 zinc finger and BTB domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_848859.1

Status: VALIDATED

Source sequence(s)

AC124453, BQ032048

Consensus CDS

CCDS25992.1

UniProtKB/Swiss-Prot

Q8CDP7, Q91VL9, Q99LD2

UniProtKB/TrEMBL

Q3V277, Q5YB37

Related

ENSMUSP00000041955.4, ENSMUST00000042779.4

Conserved Domains (3) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:688 → 709

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

76416825..76443729

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515898.3 → XP_006515961.1 zinc finger and BTB domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

Q3V277

Conserved Domains (3) summary

sd00017
Location:536 → 574

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

pfam13465
Location:592 → 617

zf-H2C2_2; Zinc-finger double domain
XM_006515895.4 → XP_006515958.1 zinc finger and BTB domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006515958.1

UniProtKB/Swiss-Prot

Q8CDP7, Q91VL9, Q99LD2

UniProtKB/TrEMBL

Q3V277, Q5YB37

Conserved Domains (3) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:688 → 709

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)