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    Gpat3 glycerol-3-phosphate acyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 231510, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gpat3provided by MGI
    Official Full Name
    glycerol-3-phosphate acyltransferase 3provided by MGI
    Primary source
    MGI:MGI:3603816
    See related
    Ensembl:ENSMUSG00000029314 AllianceGenome:MGI:3603816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agpat9; GPAT-3; mGPAT3; 1-AGPAT; AGPAT 10; 1-AGPAT 9; 4933408F15; 4933407I02Rik; A230097K15Rik
    Summary
    Enables glycerol-3-phosphate O-acyltransferase activity. Involved in glycerol-3-phosphate metabolic process; phospholipid biosynthetic process; and triglyceride biosynthetic process. Located in endoplasmic reticulum. Orthologous to human GPAT3 (glycerol-3-phosphate acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 11.7), large intestine adult (RPKM 11.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E4; 5 48.52 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100994095..101046968)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100845665..100899102)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930458D05 gene Neighboring gene STARR-seq mESC enhancer starr_13731 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101285611-101285912 Neighboring gene predicted gene, 26286 Neighboring gene STARR-seq mESC enhancer starr_13732 Neighboring gene STARR-positive B cell enhancer ABC_E2164 Neighboring gene predicted gene, 46917 Neighboring gene STARR-positive B cell enhancer ABC_E9257 Neighboring gene STARR-positive B cell enhancer ABC_E4769 Neighboring gene predicted gene, 36793 Neighboring gene predicted gene, 36740 Neighboring gene STARR-seq mESC enhancer starr_13733 Neighboring gene STARR-seq mESC enhancer starr_13734 Neighboring gene predicted gene, 36851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis. Khatun I, et al. J Biol Chem, 2016 Feb 5. PMID 26644473, Free PMC Article
    2. Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity. Cao J, et al. Am J Physiol Endocrinol Metab, 2014 May 15. PMID 24714397
    3. Triacylglycerol synthesis directed by glycerol-3-phosphate acyltransferases -3 and -4 is required for lipid droplet formation and the modulation of the inflammatory response during macrophage to foam cell transition. Quiroga IY, et al. Atherosclerosis, 2021 Jan. PMID 33260006, Free PMC Article
    4. GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Gao M, et al. Hum Mol Genet, 2020 Feb 1. PMID 31873720
    5. Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages. Quiroga IY, et al. Biochem J, 2019 Jan 11. PMID 30523059

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy.
      Title: GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy.
    2. Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
      Title: Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
    3. glycerolipid synthesis is induced during macrophage activation. GPAT4 protein level and GPAT3/GPAT4 enzymatic activity increase during this process, and these two isoforms were required for the accumulation of cell TAG and PL.
      Title: Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages.
    4. These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT.
      Title: SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase.
    5. These studies identify GPAT3 as a novel enzyme involved in intestinal lipid metabolism.
      Title: Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis.
    6. GPAT3 is the primary GPAT in white adipose tissue and has an important role of the enzyme in regulating energy, glucose, and lipid homeostasis.
      Title: Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol-3-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 3
    Names
    1-AGP acyltransferase 9
    1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10
    1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9
    1-acylglycerol-3-phosphate O-acyltransferase 9
    LPAAT-theta
    acyl-CoA:glycerol-3-phosphate acyltransferase 3
    lysophosphatidic acid acyltransferase theta
    NP_766303.1
    XP_011247735.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172715.3 → NP_766303.1  glycerol-3-phosphate acyltransferase 3

      See identical proteins and their annotated locations for NP_766303.1

      Status: VALIDATED

      Source sequence(s)
      AC107774, AI462140, AK160261, BY012233, CN719213
      Consensus CDS
      CCDS19470.1
      UniProtKB/Swiss-Prot
      A6H5X0, Q8C0N2
      Related
      ENSMUSP00000031255.9, ENSMUST00000031255.15
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100994095..101046968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249433.3 → XP_011247735.1  glycerol-3-phosphate acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011247735.1

      UniProtKB/Swiss-Prot
      A6H5X0, Q8C0N2
      Related
      ENSMUSP00000090667.4, ENSMUST00000092990.4
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0N2.1 GenPept UniProtKB/Swiss-Prot:Q8C0N2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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