Ccne2 cyclin E2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccne2provided by MGI
Official Full Name: cyclin E2provided by MGI
Primary source: MGI:MGI:1329034
See related: Ensembl:ENSMUSG00000028212 AllianceGenome:MGI:1329034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and regulation of protein localization. Part of cyclin E2-CDK2 complex. Is expressed in several structures, including cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 11.2), liver E14.5 (RPKM 8.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 5.07 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (11190489..11204781)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (11190433..11204779)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High CCNE2 expression is associated with hepatitis and hepatocarcinogenesis.
Title: Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.
This approach allowed us to determine the identity of cyclin E protein partners, as well as phosphorylation substrates of cyclins E (cyclin E1and cyclin E2)and its associated kinase, Cdk2, in different mouse organs.
Title: Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.
Spermatocytes lacking cyclin E2 and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages.
Title: E-type cyclins modulate telomere integrity in mammalian male meiosis.
These results highlight a new role for E-type cyclins (Ccne1 and Ccne2) as important regulators of male meiosis.
Title: Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.
CaM-dependent cyclin E/CDK2 activity is mediator of known Ca2+ sensitivity of G1/S transition of vascular smooth muscle cells.
Title: A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1/s transitions in vascular smooth muscle cells.
During embryonic development, the needs for this cyclin can be overcome in mitotic cycles but not in endoreplicating cells.
Title: Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.
These findings define a molecular function for E type cyclins (cyclins E1 and E2) in cell cycle reentry and reveal a differential requirement for cyclin E in normal versus oncogenic proliferation.
Title: Cyclin E ablation in the mouse.
We propose that such increased E2F activity stabilizes cyclin E and contributes to establish the high and persistent levels of the protein commonly found in human neoplasias.
Title: Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation.
This work indicates that-in addition to their function as CDK activators-E cyclins play kinase-independent functions in cell-cycle progression.
Title: Kinase-independent function of cyclin E.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AV063769 (e-PCR)
- UniSTS:178970

UniSTS:496751 (e-PCR)
- UniSTS:496751

Ccne2 (e-PCR), detects polymorphism
- UniSTS:496751

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin E1-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin E2-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin E2-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G1/S-specific cyclin-E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037134.3 → NP_001032211.1 G1/S-specific cyclin-E2 isoform 1

See identical proteins and their annotated locations for NP_001032211.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 3 and 5 encode the same isoform (1).

Source sequence(s)

AL840625

Consensus CDS

CCDS17965.1

UniProtKB/Swiss-Prot

Q9QWU5, Q9Z238

UniProtKB/TrEMBL

Q544H6, Q7TMS8

Related

ENSMUSP00000130693.2, ENSMUST00000170901.8

Conserved Domains (2) summary

pfam00134
Location:112 → 239

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:241 → 361

Cyclin_C; Cyclin, C-terminal domain
NM_001282943.2 → NP_001269872.1 G1/S-specific cyclin-E2 isoform 1

See identical proteins and their annotated locations for NP_001269872.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).

Source sequence(s)

AL840625

Consensus CDS

CCDS17965.1

UniProtKB/Swiss-Prot

Q9QWU5, Q9Z238

UniProtKB/TrEMBL

Q544H6, Q7TMS8

Related

ENSMUSP00000103960.4, ENSMUST00000108324.4

Conserved Domains (2) summary

pfam00134
Location:112 → 239

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:241 → 361

Cyclin_C; Cyclin, C-terminal domain
NM_001419967.1 → NP_001406896.1 G1/S-specific cyclin-E2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AL840625

UniProtKB/TrEMBL

A2API1
NM_001419968.1 → NP_001406897.1 G1/S-specific cyclin-E2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to varian 1. Variants 1, 3 and 5 encode the same isoform (1).

Source sequence(s)

AL840625

UniProtKB/Swiss-Prot

Q9QWU5, Q9Z238

UniProtKB/TrEMBL

Q544H6
NM_001419969.1 → NP_001406898.1 G1/S-specific cyclin-E2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and differs in the 5' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AL840625

UniProtKB/TrEMBL

A2API1
NM_009830.4 → NP_033960.1 G1/S-specific cyclin-E2 isoform 2

See identical proteins and their annotated locations for NP_033960.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AL840625

Consensus CDS

CCDS17966.1

UniProtKB/TrEMBL

A2API1, Q7TMS8

Related

ENSMUSP00000029866.10, ENSMUST00000029866.16

Conserved Domains (2) summary

pfam00134
Location:111 → 238

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:240 → 360

Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

11190489..11204781

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537574.5 → XP_006537637.1 G1/S-specific cyclin-E2 isoform X1

See identical proteins and their annotated locations for XP_006537637.1

UniProtKB/Swiss-Prot

Q9QWU5, Q9Z238

UniProtKB/TrEMBL

Q544H6, Q7TMS8

Conserved Domains (2) summary

pfam00134
Location:112 → 239

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:241 → 361

Cyclin_C; Cyclin, C-terminal domain